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Mar. Drugs 2018, 16(9), 329; https://doi.org/10.3390/md16090329

Highly Substituted Benzophenone Aldehydes and Eremophilane Derivatives from the Deep-Sea Derived Fungus Phomopsis lithocarpus FS508

1
State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China
2
College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
3
Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 10 August 2018 / Revised: 5 September 2018 / Accepted: 7 September 2018 / Published: 11 September 2018
(This article belongs to the Special Issue Natural Products from Marine Fungi)
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Abstract

Five new benzophenone derivatives named tenellones D–H (15), sharing a rare naturally occurring aldehyde functionality in this family, and a new eremophilane derivative named lithocarin A (7), together with two known compounds (6 and 8), were isolated from the deep marine sediment-derived fungus Phomopsis lithocarpus FS508. All of the structures for these new compounds were fully characterized and established on the basis of extensive spectroscopic interpretation and X-ray crystallographic analysis. Compound 5 exhibited cytotoxic activity against HepG-2 and A549 cell lines with IC50 values of 16.0 and 17.6 μM, respectively. View Full-Text
Keywords: deep-sea derived fungus; Phomopsis lithocarpus; benzophenone derivatives; eremophilane derivative deep-sea derived fungus; Phomopsis lithocarpus; benzophenone derivatives; eremophilane derivative
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Xu, J.-L.; Liu, H.-X.; Chen, Y.-C.; Tan, H.-B.; Guo, H.; Xu, L.-Q.; Li, S.-N.; Huang, Z.-L.; Li, H.-H.; Gao, X.-X.; Zhang, W.-M. Highly Substituted Benzophenone Aldehydes and Eremophilane Derivatives from the Deep-Sea Derived Fungus Phomopsis lithocarpus FS508. Mar. Drugs 2018, 16, 329.

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