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Mar. Drugs 2018, 16(9), 330; https://doi.org/10.3390/md16090330

New Antibacterial Bagremycins F and G from the Marine-Derived Streptomyces sp. ZZ745

1,†
,
2,†
,
2,* and 1,*
1
Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan 316021, China
2
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
These authors contributed equal to this work.
*
Authors to whom correspondence should be addressed.
Received: 11 August 2018 / Revised: 30 August 2018 / Accepted: 10 September 2018 / Published: 12 September 2018
(This article belongs to the Special Issue Natural Products from Marine Actinomycetes)
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Abstract

As part of our research to discover novel bioactive natural products from marine microorganisms, five bagremycin analogues, including the previously unreported bagremycins F (1) and G (2), were isolated from a marine actinomycete Streptomyces sp. ZZ745. The structures of these compounds were determined by means of NMR spectroscopic analysis, HRESIMS data, and optical rotation. Both bagremycins F (1) and G (2) showed antibacterial activity against Escherichia coli, with MIC values of 41.8 and 61.7 μM, respectively. View Full-Text
Keywords: Streptomyces sp. ZZ745; bagremycin F; bagremycin G; antibacterial activity Streptomyces sp. ZZ745; bagremycin F; bagremycin G; antibacterial activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhang, D.; Shu, C.; Lian, X.; Zhang, Z. New Antibacterial Bagremycins F and G from the Marine-Derived Streptomyces sp. ZZ745. Mar. Drugs 2018, 16, 330.

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