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Mar. Drugs 2018, 16(8), 278; https://doi.org/10.3390/md16080278

Cembranoid-Related Metabolites and Biological Activities from the Soft Coral Sinularia flexibilis

1
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
2
School of Pharmacy, China Medical University, Taichung 404, Taiwan
3
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
4
Graduate Institute of Natural Products, College of Medicine, and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan
5
Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
6
Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
7
Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan
8
Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
9
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
10
Frontier Center for Ocean Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 6 July 2018 / Revised: 1 August 2018 / Accepted: 7 August 2018 / Published: 9 August 2018
(This article belongs to the Special Issue Marine Natural Products Discovery: In Honor of Late Prof. Tatsuo Higa)
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Abstract

Five new cembranoid-related diterpenoids, namely, flexibilisins D and E (1 and 2), secoflexibilisolides A and B (3 and 4), and flexibilisolide H (5), along with nine known compounds (614), were isolated from the soft coral Sinularia flexibilis. Their structures were established by extensive spectral analysis. Compound 3 possesses an unusual skeleton that could be biogenetically derived from cembranoids. The cytotoxicity and anti-inflammatory activities of the isolates were investigated, and the results showed that dehydrosinulariolide (7) and 11-epi-sinulariolide acetate (8) exhibited cytotoxicity toward a limited panel of cancer cell lines and 14-deoxycrassin (9) displayed anti-inflammatory activity by inhibition of superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced human neutrophils. View Full-Text
Keywords: cembranoid-related compounds; flexibilisin; secoflexibilisolide; flexibilisolide; Sinularia flexibilis cembranoid-related compounds; flexibilisin; secoflexibilisolide; flexibilisolide; Sinularia flexibilis
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Wu, C.-H.; Chao, C.-H.; Huang, T.-Z.; Huang, C.-Y.; Hwang, T.-L.; Dai, C.-F.; Sheu, J.-H. Cembranoid-Related Metabolites and Biological Activities from the Soft Coral Sinularia flexibilis. Mar. Drugs 2018, 16, 278.

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