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Mar. Drugs 2018, 16(8), 254; https://doi.org/10.3390/md16080254

Absorption Study of Mozuku Fucoidan in Japanese Volunteers

1
South Product Co., LTD., Uruma, Okinawa 904-2234, Japan
2
Graduate School of Health Science, Gunma University, Honorary Professor of Gunma University, Maebashi, Gunma 371-8511, Japan
*
Author to whom correspondence should be addressed.
Received: 14 June 2018 / Revised: 27 June 2018 / Accepted: 28 July 2018 / Published: 30 July 2018
(This article belongs to the Special Issue Marine Natural Products Discovery: In Honor of Late Prof. Tatsuo Higa)
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Abstract

We performed an oral administration study of fucoidan in 396 Japanese volunteers and investigated significant factors concerning the absorption of fucoidan. Urine samples were collected at 0, 3, 6, and 9 h after ingestion of 3 g of fucoidan. Fucoidan was detected in urine after ingestion in 385 out of 396 subjects. The maximum value (mean ± standard deviation (SD)) of urinary fucoidan was 332.3 ± 357.6 μg/gCr in subjects living in Okinawa prefecture, compared with 240.1 ± 302.4 μg/gCr in subjects living outside Okinawa. Compared with the estimated urinary excretion of fucoidan by place of residence, those of subjects living in Okinawa prefecture were significantly higher than those living outside Okinawa prefecture (p < 0.01). In addition, subjects living in Okinawa prefecture consumed significantly greater amounts of mozuku compared with those living outside Okinawa prefecture (p < 0.01). Multiple regression analysis showed that having Okinawa prefecture as a place of residence was a significant factor (p < 0.01) contributing to the estimated urinary excretion of fucoidan. Because the habit of eating mozuku was significantly higher (p < 0.01) in subjects living in Okinawa prefecture than in those living outside Okinawa prefecture, the habit of eating mozuku was speculated to be a factor in the absorption of fucoidan. View Full-Text
Keywords: fucoidan absorption; urinary fucoidan value; inhabitants of Okinawa prefecture; mozuku consumption fucoidan absorption; urinary fucoidan value; inhabitants of Okinawa prefecture; mozuku consumption
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Kadena, K.; Tomori, M.; Iha, M.; Nagamine, T. Absorption Study of Mozuku Fucoidan in Japanese Volunteers. Mar. Drugs 2018, 16, 254.

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