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Mar. Drugs 2018, 16(7), 226; https://doi.org/10.3390/md16070226

Sorbicillinoid-Based Metabolites from a Sponge-Derived Fungus Trichoderma saturnisporum

1
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China
2
Food and Medicine College, Zhejiang Ocean University, Zhoushan 316022, China
3
Department of Pharmacoguosy, Faculty of Pharmacy, Ankara University, Tandogan, Ankara 06100, Turkiye
4
College of Veterinary Medicine, China Agricultural University, Beijing 100193, China
These authors contributed equal to this work.
*
Author to whom correspondence should be addressed.
Received: 8 June 2018 / Revised: 21 June 2018 / Accepted: 27 June 2018 / Published: 4 July 2018
(This article belongs to the Special Issue Marine Natural Products from Symbiotic Ecosystems)
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Abstract

Antibacterial activity assessment and high performance liquid chromatography associated with nuclear magnetic resonance (HPLC/NMR) data revealed that the EtOAc extract of the fermented endophytic fungus Trichoderma saturnisporum DI-IA, obtained from the marine sponge Dictyonella incisa, contained conjugated olefinic metabolites with antibacterial activity. Chemical examination of the fungal strain resulted in the isolation of eight new sorbicillinoid-based compounds, namely saturnispols A–H (18). Their structures were determined on the basis of extensive spectroscopic analysis, including the experimental and calculated electronic circular dichroism (ECD) data for the configurational assignments. Saturnispol F exerted significant inhibition against a panel of bacteria strains including vancomycin-resistant enterococci (VRE) with a minimum inhibitory concentrations (MIC) ranging from 1.63 to 12.9 μg/mL, while saturnispol H showed selective effects against VRE and B. subtilis. View Full-Text
Keywords: marine fungus; Trichoderma saturnisporum; saturnispols A–H; structural elucidation; antibacterial effects marine fungus; Trichoderma saturnisporum; saturnispols A–H; structural elucidation; antibacterial effects
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Meng, J.; Cheng, W.; Heydari, H.; Wang, B.; Zhu, K.; Konuklugil, B.; Lin, W. Sorbicillinoid-Based Metabolites from a Sponge-Derived Fungus Trichoderma saturnisporum. Mar. Drugs 2018, 16, 226.

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