Bioactive Pyridone Alkaloids from a Deep-Sea-Derived Fungus Arthrinium sp. UJNMF0008
AbstractEight new 4-hydroxy-2-pyridone alkaloids arthpyrones D–K (1–8), along with two known analogues apiosporamide (9) and arthpyrone B (10), were isolated from a deep-sea-derived fungus Arthrinium sp. UJNMF0008. The structures of the isolated compounds were elucidated on the basis of spectroscopic methods with that of 1 being established by chemical transformation and X-ray diffraction analysis. Compounds 1 and 2 bore an ester functionality linking the pyridone and decalin moieties first reported in this class of metabolites, while 3 and 4 incorporated a rare natural hexa- or tetrahydrobenzofuro[3,2-c]pyridin-3(2H)-one motif. Compounds 3–6 and 9 exhibited moderate to significant antibacterial activity against Mycobacterium smegmatis and Staphylococcus aureus with IC50 values ranging from 1.66–42.8 μM, while 9 displayed cytotoxicity against two human osteosarcoma cell lines (U2OS and MG63) with IC50 values of 19.3 and 11.7 μM, respectively. View Full-Text
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Bao, J.; Zhai, H.; Zhu, K.; Yu, J.-H.; Zhang, Y.; Wang, Y.; Jiang, C.-S.; Zhang, X.; Zhang, Y.; Zhang, H. Bioactive Pyridone Alkaloids from a Deep-Sea-Derived Fungus Arthrinium sp. UJNMF0008. Mar. Drugs 2018, 16, 174.
Bao J, Zhai H, Zhu K, Yu J-H, Zhang Y, Wang Y, Jiang C-S, Zhang X, Zhang Y, Zhang H. Bioactive Pyridone Alkaloids from a Deep-Sea-Derived Fungus Arthrinium sp. UJNMF0008. Marine Drugs. 2018; 16(5):174.Chicago/Turabian Style
Bao, Jie; Zhai, Huijuan; Zhu, Kongkai; Yu, Jin-Hai; Zhang, Yuying; Wang, Yinyin; Jiang, Cheng-Shi; Zhang, Xiaoyong; Zhang, Yun; Zhang, Hua. 2018. "Bioactive Pyridone Alkaloids from a Deep-Sea-Derived Fungus Arthrinium sp. UJNMF0008." Mar. Drugs 16, no. 5: 174.
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