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Mar. Drugs 2018, 16(5), 170; https://doi.org/10.3390/md16050170

Glycosaminoglycans from a Sea Snake (Lapemis curtus): Extraction, Structural Characterization and Antioxidant Activity

1
Key Laboratory of Marine Drugs, Ministry of Education, Shandong Provincial Key laboratory of Glycoscience and Glycoengineering, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
2
Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China
3
Marine Biomedical Research Institute of Qingdao, Qingdao 266071, China
4
Ocean College of Hainan University, Haikou 570228, China
*
Author to whom correspondence should be addressed.
Received: 10 April 2018 / Revised: 7 May 2018 / Accepted: 10 May 2018 / Published: 18 May 2018
(This article belongs to the Collection Marine Polysaccharides)
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Abstract

Sea snakes have wide application prospects in medicine, health food and other fields. Several novel polysaccharides were successfully obtained from the skin and the meat of a sea snake (Lapemis curtus). The structures of polysaccharides LSP3 and LMP3, which were extracted and purified from Lapemis curtus, were determined to be new and highly heterogenic glycosaminoglycans (GAGs) by means of FT-IR, ESI-MS/MS and NMR. LSP3 is a hybrid dermatan sulfate (DS) and composed of 48% 4-sulfated disaccharides (Di4S), 42% 6-sulfated disaccharides (Di6S) and 5% disulfated disaccharides (Di2,6S), while LMP3 is a hybrid chondroitin sulfate (CS) and composed of 70% Di4S, 20% Di6S, and 8% Di2,6S. More importantly, LSP3 and LMP3 showed a strong scavenging ability of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, iron (Fe2+) chelating activity and total antioxidant capacity in vitro, especially LSP3, with high contents of uronic acid and sulfate, which possessed a higher scavenging ability of DPPH radicals than other fractions. These data suggested that the sea snake polysaccharides could be promising candidates for natural antioxidant ingredients. View Full-Text
Keywords: Lapemis curtus; glycosaminoglycans; chondroitin sulfate; dermatan sulfate; structural characterization; antioxidant activities Lapemis curtus; glycosaminoglycans; chondroitin sulfate; dermatan sulfate; structural characterization; antioxidant activities
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Bai, M.; Han, W.; Zhao, X.; Wang, Q.; Gao, Y.; Deng, S. Glycosaminoglycans from a Sea Snake (Lapemis curtus): Extraction, Structural Characterization and Antioxidant Activity. Mar. Drugs 2018, 16, 170.

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