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Mar. Drugs 2017, 15(9), 276; doi:10.3390/md15090276

Palladium-Catalyzed Dehydrogenative Coupling: An Efficient Synthetic Strategy for the Construction of the Quinoline Core

Departamento de Química Orgánica II, Facultad de Ciencia y Tecnología, Universidad del País Vasco/Euskal Herriko Unibertsitatea UPV/EHU, Apdo. 644, 48080 Bilbao, Spain
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Authors to whom correspondence should be addressed.
Academic Editor: Mercedes Álvarez
Received: 19 July 2017 / Revised: 4 August 2017 / Accepted: 24 August 2017 / Published: 30 August 2017
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Abstract

Palladium-catalyzed dehydrogenative coupling is an efficient synthetic strategy for the construction of quinoline scaffolds, a privileged structure and prevalent motif in many natural and biologically active products, in particular in marine alkaloids. Thus, quinolines and 1,2-dihydroquinolines can be selectively obtained in moderate-to-good yields via intramolecular C–H alkenylation reactions, by choosing the reaction conditions. This methodology provides a direct method for the construction of this type of quinoline through an efficient and atom economical procedure, and constitutes significant advance over the existing procedures that require preactivated reaction partners. View Full-Text
Keywords: quinoline; synthesis; palladium; coupling; C–H alkenylation quinoline; synthesis; palladium; coupling; C–H alkenylation
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Carral-Menoyo, A.; Ortiz-de-Elguea, V.; Martinez-Nunes, M.; Sotomayor, N.; Lete, E. Palladium-Catalyzed Dehydrogenative Coupling: An Efficient Synthetic Strategy for the Construction of the Quinoline Core. Mar. Drugs 2017, 15, 276.

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