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Mar. Drugs 2017, 15(11), 361; doi:10.3390/md15110361

The Oxepane Motif in Marine Drugs

1
GIR MIOMeT, IU CINQUIMA/Inorganic Chemistry, University of Valladolid, Campus Miguel Delibes, 47011 Valladolid, Spain
2
Department of Organic Chemistry, University of Valladolid, Campus Miguel Delibes, 47011 Valladolid, Spain
*
Author to whom correspondence should be addressed.
Received: 29 September 2017 / Revised: 3 November 2017 / Accepted: 8 November 2017 / Published: 15 November 2017

Abstract

Oceans have shown to be a remarkable source of natural products. The biological properties of many of these compounds have helped to produce great advances in medicinal chemistry. Within them, marine natural products containing an oxepanyl ring are present in a great variety of algae, sponges, fungus and corals and show very important biological activities, many of them possessing remarkable cytotoxic properties against a wide range of cancer cell lines. Their rich chemical structures have attracted the attention of many researchers who have reported interesting synthetic approaches to these targets. This review covers the most prominent examples of these types of compounds, focusing the discussion on the isolation, structure determination, medicinal properties and total synthesis of these products. View Full-Text
Keywords: marine drugs; oxepanes; total synthesis; biological activity marine drugs; oxepanes; total synthesis; biological activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Barbero, H.; Díez-Poza, C.; Barbero, A. The Oxepane Motif in Marine Drugs. Mar. Drugs 2017, 15, 361.

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