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Mar. Drugs 2017, 15(9), 272; doi:10.3390/md15090272

Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials

1
Department of Food Biosciences, Teagasc Food Research Centre Ashtown, Dublin D15 KN3K, Ireland
2
School of Microbiology, University College Cork, Western Road, Cork City T12 YN60, Ireland
3
Department of Immunology, Microbiology and Parasitology, Faculty of Science, University of the Basque Country, (UPV/EHU), 48940 Leioa, Spain
*
Author to whom correspondence should be addressed.
Received: 20 July 2017 / Revised: 12 August 2017 / Accepted: 23 August 2017 / Published: 28 August 2017
(This article belongs to the Special Issue Genome Mining and Marine Microbial Natural Products)
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Abstract

The marine environment is a rich source of chemically diverse, biologically active natural products, and serves as an invaluable resource in the ongoing search for novel antimicrobial compounds. Recent advances in extraction and isolation techniques, and in state-of-the-art technologies involved in organic synthesis and chemical structure elucidation, have accelerated the numbers of antimicrobial molecules originating from the ocean moving into clinical trials. The chemical diversity associated with these marine-derived molecules is immense, varying from simple linear peptides and fatty acids to complex alkaloids, terpenes and polyketides, etc. Such an array of structurally distinct molecules performs functionally diverse biological activities against many pathogenic bacteria and fungi, making marine-derived natural products valuable commodities, particularly in the current age of antimicrobial resistance. In this review, we have highlighted several marine-derived natural products (and their synthetic derivatives), which have gained recognition as effective antimicrobial agents over the past five years (2012–2017). These natural products have been categorized based on their chemical structures and the structure-activity mediated relationships of some of these bioactive molecules have been discussed. Finally, we have provided an insight into how genome mining efforts are likely to expedite the discovery of novel antimicrobial compounds. View Full-Text
Keywords: antimicrobial; marine natural products (MNPs); secondary metabolites; antibacterial; antifungal; genome mining antimicrobial; marine natural products (MNPs); secondary metabolites; antibacterial; antifungal; genome mining
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Choudhary, A.; Naughton, L.M.; Montánchez, I.; Dobson, A.D.W.; Rai, D.K. Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials. Mar. Drugs 2017, 15, 272.

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