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Mar. Drugs 2017, 15(8), 249; doi:10.3390/md15080249

Two Furanosesterterpenoids from the Sponge Luffariella variabilis

1
Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan
2
Naturalis Biodiversity Center, P.O. Box 9517, 2300 RA Leiden, The Netherlands
*
Author to whom correspondence should be addressed.
Received: 3 July 2017 / Revised: 3 August 2017 / Accepted: 7 August 2017 / Published: 10 August 2017
(This article belongs to the Collection Bioactive Compounds from Marine Invertebrates)
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Abstract

Two new sesterterpenoids, 1 and 2, were isolated from the sponge Luffariella variabilis. Their planar structures were characterized with spectroscopic analyses. The sole chiral center of compound 1 was elucidated as 12R by comparing observed and calculated optical rotation values. The configurations of compound 2 were determined by NMR and electronic circular dichroism (ECD) studies. Furthermore, compound 2 showed cytotoxicity at IC50 1.0 µM against NBT-T2 cells. View Full-Text
Keywords: sesterterpenoid; sponge; cytotoxicity sesterterpenoid; sponge; cytotoxicity
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Ahmadi, P.; Higashi, M.; Voogd, N.J.; Tanaka, J. Two Furanosesterterpenoids from the Sponge Luffariella variabilis. Mar. Drugs 2017, 15, 249.

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