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Mar. Drugs 2017, 15(7), 212; doi:10.3390/md15070212

Sterols from the Octocoral Nephthea columnaris

1,2,†
,
3,4,†
,
2
,
5,6,7,* and 1,2,8,9,10,*
1
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
2
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
3
Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
4
Department of Neurosurgery, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
5
Graduate Institute of Natural Products, College of Medicine and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan
6
Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
7
Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
8
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
9
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
10
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 23 May 2017 / Revised: 26 June 2017 / Accepted: 1 July 2017 / Published: 4 July 2017
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
View Full-Text   |   Download PDF [1262 KB, uploaded 4 July 2017]   |  

Abstract

Two new sterols, columnaristerols B (1) and C (2), along with two known analogues, 5,6-epoxylitosterol (3) and litosterol (4), were obtained from the octocoral Nephthea columnaris. The structures of new sterols 1 and 2 were elucidated by using spectroscopic methods and comparing the spectroscopic data with those of known related metabolites. Sterol 3 was found to suppress superoxide anion production and elastase secretion by human neutrophils. View Full-Text
Keywords: octocoral; Nephthea columnaris; columnaristerol; litosterol; superoxide anion; elastase octocoral; Nephthea columnaris; columnaristerol; litosterol; superoxide anion; elastase
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MDPI and ACS Style

Whuang, T.-Y.; Tsai, H.-C.; Su, Y.-D.; Hwang, T.-L.; Sung, P.-J. Sterols from the Octocoral Nephthea columnaris. Mar. Drugs 2017, 15, 212.

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