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Mar. Drugs 2017, 15(6), 190; doi:10.3390/md15060190

The Identification of a SIRT6 Activator from Brown Algae Fucus distichus

1
Biomedical Research Center, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA
2
School of Pharmacy, University of Eastern Finland, Kuopio FI-70210, Finland
3
Food Biosciences Department, Teagasc Food Research Centre, Ashtown, Dublin 15, Ireland
*
Author to whom correspondence should be addressed.
Received: 22 May 2017 / Revised: 13 June 2017 / Accepted: 16 June 2017 / Published: 21 June 2017
(This article belongs to the Collection Marine Polysaccharides)
View Full-Text   |   Download PDF [1755 KB, uploaded 21 June 2017]   |  

Abstract

Brown seaweeds contain many bioactive compounds, including polyphenols, polysaccharides, fucosterol, and fucoxantin. These compounds have several biological activities, including anti-inflammatory, hepatoprotective, anti-tumor, anti-hypertensive, and anti-diabetic activity, although in most cases their mechanisms of action are not understood. In this study, extracts generated from five brown algae (Fucus dichitus, Fucus vesiculosus (Linnaeus), Cytoseira tamariscofolia, Cytoseira nodacaulis, Alaria esculenta) were tested for their ability to activate SIRT6 resulting in H3K9 deacetylation. Three of the five macroalgal extracts caused a significant increase of H3K9 deacetylation, and the effect was most pronounced for F. dichitus. The compound responsible for this in vitro activity was identified by mass spectrometry as fucoidan. View Full-Text
Keywords: sirtuin activators; fucoidan; brown seaweed sirtuin activators; fucoidan; brown seaweed
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Rahnasto-Rilla, M.K.; McLoughlin, P.; Kulikowicz, T.; Doyle, M.; Bohr, V.A.; Lahtela-Kakkonen, M.; Ferrucci, L.; Hayes, M.; Moaddel, R. The Identification of a SIRT6 Activator from Brown Algae Fucus distichus. Mar. Drugs 2017, 15, 190.

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