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Mar. Drugs 2017, 15(6), 177; doi:10.3390/md15060177

Crellasterones A and B: A-Norsterol Derivatives from the New Caledonian Sponge Crella incrustans

Department of Chemistry & Biomolecular Sciences, Macquarie University, Sydney NSW 2109, Australia
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Received: 5 June 2017 / Revised: 10 June 2017 / Accepted: 13 June 2017 / Published: 15 June 2017
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Abstract

Two new steroids, crellasterones A (1) and B (2), together with the previously reported compound chalinasterol (3) and several nucleosides (47), were isolated from the sponge Crella incrustans, collected in New Caledonia. The structures of the new compounds were established by extensive NMR and mass spectroscopic analysis and revealed unprecedented marine natural products with a ring-contracted A-norsterone nucleus and 2-hydroxycyclopentenone chromophore. The absolute configurations were derived from electronic circular dichroism (ECD) measurements in conjunction with high-level density functional theory (DFT) calculations. View Full-Text
Keywords: steroid; crellasterone; Crella; sponge; DFT; marine natural products steroid; crellasterone; Crella; sponge; DFT; marine natural products
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ragini, K.; Piggott, A.M.; Karuso, P. Crellasterones A and B: A-Norsterol Derivatives from the New Caledonian Sponge Crella incrustans. Mar. Drugs 2017, 15, 177.

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