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Mar. Drugs 2017, 15(6), 168; doi:10.3390/md15060168

Higher Anti-Liver Fibrosis Effect of Cordyceps militaris-Fermented Product Cultured with Deep Ocean Water via Inhibiting Proinflammatory Factors and Fibrosis-Related Factors Expressions

Department of Life Science, National Taitung University, 369, Section 2, University Rd., Taitung 95092, Taiwan
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Author to whom correspondence should be addressed.
Academic Editor: Olivier P. Thomas
Received: 2 February 2017 / Revised: 26 March 2017 / Accepted: 1 June 2017 / Published: 8 June 2017
(This article belongs to the Special Issue Marine Compounds and Inflammation II, 2017)
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Abstract

Deep ocean water (DOW) has been shown to enhance the functional components of fungi, resulting in increased health benefits. Therefore, using DOW for culturing fungi can enhance the cordycepin and adenosine of Cordyceps militaris (CM) and its protective effects on the liver. In this study, the antiliver fibrosis effects and mechanisms of ultrapure water-cultured CM (UCM), DOW-cultured CM (DCM), synthetic water-cultured CM, DOW, cordycepin, and adenosine were compared in the liver fibrosis mice induced by intraperitoneal injections of thioacetamide (TAA). The results indicated that DCM exhibited superior performance in reducing liver collagen accumulation, mitigating liver injuries, inhibiting proinflammatory factors and fibrosis-related factor (TGF-β1, Smad2/3, α-SMA, COL1A1) expression compared with UCM. DOW, cordycepin, and adenosine also performed antiliver fibrosis effect. Therefore, because DCM is rich in DOW and functional components, it can achieve anti-liver fibrosis effects through multiple pathways. These ameliorative effects are considerably superior to those of UCM. View Full-Text
Keywords: liver fibrosis; deep ocean water; Cordyceps militaris; cordycepin; adenosine liver fibrosis; deep ocean water; Cordyceps militaris; cordycepin; adenosine
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Hung, Y.-P.; Lee, C.-L. Higher Anti-Liver Fibrosis Effect of Cordyceps militaris-Fermented Product Cultured with Deep Ocean Water via Inhibiting Proinflammatory Factors and Fibrosis-Related Factors Expressions. Mar. Drugs 2017, 15, 168.

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