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Mar. Drugs 2017, 15(6), 150; doi:10.3390/md15060150

Two New Oxodolastane Diterpenes from the Jamaican Macroalga Canistrocarpus cervicornis

1
Department of Chemistry, University of the West Indies, Mona Campus, St. Andrew JMAAW15, Jamaica
2
Natural Products Institute, University of the West Indies, Mona Campus, St. Andrew JMAAW15, Jamaica
*
Author to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Received: 7 April 2017 / Revised: 9 May 2017 / Accepted: 22 May 2017 / Published: 30 May 2017
View Full-Text   |   Download PDF [751 KB, uploaded 30 May 2017]   |  

Abstract

The chemical investigation of the organic extract of Canistrocarpus cervicornis, collected at Drunken Man’s Cay at Port Royal, Jamaica, has led to the isolation of two new dolastane diterpenes 4R-acetoxy-8S,9S-epoxy-14S-hydroxy-7-oxodolastane (1) and 4R-hydroxy-8S,9S-epoxy-14S-hydroxy-7-oxodolastane (2) and the previously isolated dolastane (4R,9S,14S)-4,9,14-trihydroxydolast-1(15),7-diene (3) as a major diterpene constituent. The structures of the new compounds were elucidated by extensive spectroscopic analyses. Compounds 13 were evaluated for their cytotoxicity against human tumor cell lines PC3 and HT29. The results revealed that the dolastane diterpenes (13) displayed moderate, concentration dependent, cytotoxicity. View Full-Text
Keywords: dolastane; diterpenes; Canistrocarpus cervicornis dolastane; diterpenes; Canistrocarpus cervicornis
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MDPI and ACS Style

Campbell, S.; Murray, J.; Delgoda, R.; Gallimore, W. Two New Oxodolastane Diterpenes from the Jamaican Macroalga Canistrocarpus cervicornis. Mar. Drugs 2017, 15, 150.

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