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Mar. Drugs 2017, 15(6), 157; doi:10.3390/md15060157

The Missing Piece in Biosynthesis of Amphidinols: First Evidence of Glycolate as a Starter Unit in New Polyketides from Amphidinium carterae

Institute of Biomolecular Chemistry, National Research Council (CNR), Pozzuoli 80078, Naples, Italy
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Academic Editor: Paul Long
Received: 28 April 2017 / Revised: 22 May 2017 / Accepted: 25 May 2017 / Published: 31 May 2017
(This article belongs to the Special Issue Marine Microalgae)
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Abstract

Two new members of the amphidinol family, amphidinol A (1) and its 7-sulfate derivative amphidinol B (2), were isolated from a strain of Amphidinium carterae of Lake Fusaro, near Naples (Italy), and chemically identified by spectroscopic and spectrometric methods. Amphidinol A showed antifungal activity against Candida albicans (MIC = 19 µg/mL). Biosynthetic experiments with stable isotope-labelled acetate allowed defining the elongation process in 1. For the first time the use of glycolate as a starter unit in the polyketide biosynthesis of amphidinol metabolites was unambiguously demonstrated. View Full-Text
Keywords: amphidinol; amphidinol-related polyketide; Amphidinium; dinoflagellate, glycolate; polyketide biosynthesis; PKS; antifungal polyketide; Candida albicans; SHAM amphidinol; amphidinol-related polyketide; Amphidinium; dinoflagellate, glycolate; polyketide biosynthesis; PKS; antifungal polyketide; Candida albicans; SHAM
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Cutignano, A.; Nuzzo, G.; Sardo, A.; Fontana, A. The Missing Piece in Biosynthesis of Amphidinols: First Evidence of Glycolate as a Starter Unit in New Polyketides from Amphidinium carterae. Mar. Drugs 2017, 15, 157.

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