Biscembranoids and Cembranoids from the Soft Coral Sarcophyton elegans
AbstractTwo novel biscembranoids, sarelengans A and B (1 and 2), five new cembranoids, sarelengans C–G (3–7), along with two known cembranoids (8 and 9) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were determined by spectroscopic and chemical methods, and those of 1, 4, 5, and 6 were confirmed by single crystal X-ray diffraction. Compounds 1 and 2 represent the first example of biscembranoids featuring a trans-fused A/B-ring conjunction between the two cembranoid units. Their unique structures may shed light on an unusual biosynthetic pathway involving a cembranoid-∆8 rather than the normal cembranoid-∆1 unit in the endo-Diels-Alder cycloaddition. Compounds 2 and 3 exhibited potential inhibitory effects on nitric oxide production in RAW 264.7 macrophages, with IC50 values being at 18.2 and 32.5 μM, respectively. View Full-Text
- Supplementary File 1:
PDF-Document (PDF, 5034 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Li, W.; Zou, Y.-H.; Ge, M.-X.; Lou, L.-L.; Xu, Y.-S.; Ahmed, A.; Chen, Y.-Y.; Zhang, J.-S.; Tang, G.-H.; Yin, S. Biscembranoids and Cembranoids from the Soft Coral Sarcophyton elegans. Mar. Drugs 2017, 15, 85.
Li W, Zou Y-H, Ge M-X, Lou L-L, Xu Y-S, Ahmed A, Chen Y-Y, Zhang J-S, Tang G-H, Yin S. Biscembranoids and Cembranoids from the Soft Coral Sarcophyton elegans. Marine Drugs. 2017; 15(4):85.Chicago/Turabian Style
Li, Wei; Zou, Yi-Hong; Ge, Man-Xi; Lou, Lan-Lan; Xu, Yun-Shao; Ahmed, Abrar; Chen, Yun-Yun; Zhang, Jun-Sheng; Tang, Gui-Hua; Yin, Sheng. 2017. "Biscembranoids and Cembranoids from the Soft Coral Sarcophyton elegans." Mar. Drugs 15, no. 4: 85.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.