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Mar. Drugs 2017, 15(4), 85; doi:10.3390/md15040085

Biscembranoids and Cembranoids from the Soft Coral Sarcophyton elegans

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
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Author to whom correspondence should be addressed.
Academic Editors: Kirsten Benkendorff and Vassilios Roussis
Received: 13 February 2017 / Revised: 16 March 2017 / Accepted: 20 March 2017 / Published: 23 March 2017
(This article belongs to the Collection Bioactive Compounds from Marine Invertebrates)
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Abstract

Two novel biscembranoids, sarelengans A and B (1 and 2), five new cembranoids, sarelengans C–G (37), along with two known cembranoids (8 and 9) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were determined by spectroscopic and chemical methods, and those of 1, 4, 5, and 6 were confirmed by single crystal X-ray diffraction. Compounds 1 and 2 represent the first example of biscembranoids featuring a trans-fused A/B-ring conjunction between the two cembranoid units. Their unique structures may shed light on an unusual biosynthetic pathway involving a cembranoid-∆8 rather than the normal cembranoid-∆1 unit in the endo-Diels-Alder cycloaddition. Compounds 2 and 3 exhibited potential inhibitory effects on nitric oxide production in RAW 264.7 macrophages, with IC50 values being at 18.2 and 32.5 μM, respectively. View Full-Text
Keywords: Sarcophyton elegans; biscembranoids; cembranoids; NO inhibition Sarcophyton elegans; biscembranoids; cembranoids; NO inhibition
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MDPI and ACS Style

Li, W.; Zou, Y.-H.; Ge, M.-X.; Lou, L.-L.; Xu, Y.-S.; Ahmed, A.; Chen, Y.-Y.; Zhang, J.-S.; Tang, G.-H.; Yin, S. Biscembranoids and Cembranoids from the Soft Coral Sarcophyton elegans. Mar. Drugs 2017, 15, 85.

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