Bioactive Metabolites from the Deep Subseafloor Fungus Oidiodendron griseum UBOCC-A-114129
AbstractFour bioactive compounds have been isolated from the fungus Oidiodendron griseum UBOCC-A-114129 cultivated from deep subsurface sediment. They were structurally characterized using a combination of LC–MS/MS and NMR analyses as fuscin and its derivatives (dihydrofuscin, dihydrosecofuscin, and secofuscin) and identified as polyketides. Albeit those compounds were already obtained from terrestrial fungi, this is the first report of their production by an Oidiodendron species and by the deepest subseafloor isolate ever studied for biological activities. We report a weak antibacterial activity of dihydrosecofuscin and secofuscin mainly directed against Gram-positive bacteria (Minimum Inhibitory Concentration (MIC) equal to Minimum Bactericidal Concentration (MBC), in the range of 100 μg/mL). The activity on various protein kinases was also analyzed and revealed a significant inhibition of CDC2-like kinase-1 (CLK1) by dihysecofuscin. View Full-Text
- Supplementary File 1:
PDF-Document (PDF, 215 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Navarri, M.; Jégou, C.; Bondon, A.; Pottier, S.; Bach, S.; Baratte, B.; Ruchaud, S.; Barbier, G.; Burgaud, G.; Fleury, Y. Bioactive Metabolites from the Deep Subseafloor Fungus Oidiodendron griseum UBOCC-A-114129. Mar. Drugs 2017, 15, 111.
Navarri M, Jégou C, Bondon A, Pottier S, Bach S, Baratte B, Ruchaud S, Barbier G, Burgaud G, Fleury Y. Bioactive Metabolites from the Deep Subseafloor Fungus Oidiodendron griseum UBOCC-A-114129. Marine Drugs. 2017; 15(4):111.Chicago/Turabian Style
Navarri, Marion; Jégou, Camille; Bondon, Arnaud; Pottier, Sandrine; Bach, Stéphane; Baratte, Blandine; Ruchaud, Sandrine; Barbier, Georges; Burgaud, Gaëtan; Fleury, Yannick. 2017. "Bioactive Metabolites from the Deep Subseafloor Fungus Oidiodendron griseum UBOCC-A-114129." Mar. Drugs 15, no. 4: 111.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.