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Mar. Drugs 2017, 15(2), 43; doi:10.3390/md15020043

Brevianamides and Mycophenolic Acid Derivatives from the Deep-Sea-Derived Fungus Penicillium brevicompactum DFFSCS025

Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China
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Author to whom correspondence should be addressed.
Academic Editors: Sergey A. Dyshlovoy and Friedemann Honecker
Received: 29 December 2016 / Revised: 3 February 2017 / Accepted: 10 February 2017 / Published: 17 February 2017
(This article belongs to the Collection Marine Compounds and Cancer)
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Abstract

Four new compounds (14), including two brevianamides and two mycochromenic acid derivatives along with six known compounds were isolated from the deep-sea-derived fungus Penicillium brevicompactum DFFSCS025. Their structures were elucidated by spectroscopic analysis. Moreover, the absolute configurations of 1 and 2 were determined by quantum chemical calculations of the electronic circular dichroism (ECD) spectra. Compound 9 showed moderate cytotoxicity against human colon cancer HCT116 cell line with IC50 value of 15.6 μM. In addition, 3 and 5 had significant antifouling activity against Bugula neritina larval settlement with EC50 values of 13.7 and 22.6 μM, respectively. The NMR data of 6, 8, and 9 were assigned for the first time. View Full-Text
Keywords: Penicillium brevicompactum; Brevianamide; Mycochromenic acid derivative; cytotoxicity; antifouling Penicillium brevicompactum; Brevianamide; Mycochromenic acid derivative; cytotoxicity; antifouling
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Xu, X.; Zhang, X.; Nong, X.; Wang, J.; Qi, S. Brevianamides and Mycophenolic Acid Derivatives from the Deep-Sea-Derived Fungus Penicillium brevicompactum DFFSCS025. Mar. Drugs 2017, 15, 43.

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