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Mar. Drugs 2017, 15(11), 350; https://doi.org/10.3390/md15110350

Reclamation of Marine Chitinous Materials for the Production of α-Glucosidase Inhibitors via Microbial Conversion

1
Department of Science and Technology, Tay Nguyen University, Buon Ma Thuot City 630000, Vietnam
2
Department of Chemistry, Tamkang University, New Taipei City 25137, Taiwan
3
Life Science Development Center, Tamkang University, New Taipei City 25137, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: San-Lang Wang
Received: 4 October 2017 / Revised: 29 October 2017 / Accepted: 3 November 2017 / Published: 7 November 2017
(This article belongs to the Special Issue Bioconversion of Marine Resources)
View Full-Text   |   Download PDF [1160 KB, uploaded 8 November 2017]   |  

Abstract

Six kinds of chitinous materials have been used as sole carbon/nitrogen (C/N) sources for producing α-glucosidase inhibitors (aGI) by Paenibacillus sp. TKU042. The aGI productivity was found to be highest in the culture supernatants using demineralized crab shell powder (deCSP) and demineralized shrimp shell powder (deSSP) as the C/N source. The half maximal inhibitory concentration (IC50) and maximum aGI activity of fermented deCSP (38 µg/mL, 98%), deSSP (108 µg/mL, 89%), squid pen powder (SPP) (422 µg/mL, 98%), and shrimp head powder (SHP) (455 µg/mL, 92%) were compared with those of fermented nutrient broth (FNB) (81 µg/mL, 93%) and acarbose (1095 µg/mL, 74%), a commercial antidiabetic drug. The result of the protein/chitin ratio on aGI production showed that the optimal ratio was 0.2/1. Fermented deCSP showed lower IC50 and higher maximum inhibitory activity than those of acarbose against rat intestinal α-glucosidase. View Full-Text
Keywords: chitin; crab shells; α-glucosidase inhibitor; Paenibacillus; diabetes chitin; crab shells; α-glucosidase inhibitor; Paenibacillus; diabetes
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Nguyen, V.B.; Wang, S.-L. Reclamation of Marine Chitinous Materials for the Production of α-Glucosidase Inhibitors via Microbial Conversion. Mar. Drugs 2017, 15, 350.

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