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Mar. Drugs 2017, 15(10), 299; doi:10.3390/md15100299

Sterols from the Green Alga Ulva australis

Department of Natural Medicine and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, China
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Received: 12 August 2017 / Revised: 25 September 2017 / Accepted: 27 September 2017 / Published: 28 September 2017
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Abstract

Three new sterols, (24R)-5,28-stigmastadiene-3β,24-diol-7-one (1), (24S)-5,28-stigmastadiene-3β,24-diol-7-one (2), and 24R and 24S-vinylcholesta-3β,5α,6β,24-tetraol (3), together with three known sterols (46) were isolated from the green alga Ulva australis. The structures of the new compounds (13) were elucidated through 1D and 2D nuclear magnetic resonance spectroscopy as well as mass spectrometry. Compounds 46 were identified as isofucoterol (4), 24R,28S and 24S,28R-epoxy-24-ethylcholesterol (5), and (24S)-stigmastadiene-3β,24-diol (6) on the basis of spectroscopic data analyses and comparison with those reported in the literature. Compounds 46 were isolated from U. australis for the first time. These compounds, together with the previously isolated secondary metabolites of this alga, were investigated for their inhibitory effects on human recombinant aldose reductase in vitro. Of the compounds, 24R,28S and 24S,28R-epoxy-24-ethylcholesterol (5), 1-O-palmitoyl-3-O-(6′-sulfo-α-d-quinovopyranosyl) glycerol, (2S)-1-O-palmitoyl-3-O-[α-d-galactopyranosyl(1→2)β-d-galactopyranosyl] glycerol, 4-hydroxybenzoic acid, 4-hydroxyphenylacetic acid, and 8-hydroxy-(6E)-octenoic acid weakly inhibited the enzyme, while the three new sterols, 13, were almost inactive. View Full-Text
Keywords: Chlorophyta; Ulva australis; 5,28-stigmastadiene-3β,24-diol-7-one epimers; 24-vinylcholesta-3β,5α,6β,24-tetraol Chlorophyta; Ulva australis; 5,28-stigmastadiene-3β,24-diol-7-one epimers; 24-vinylcholesta-3β,5α,6β,24-tetraol
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Li, G.-L.; Guo, W.-J.; Wang, G.-B.; Wang, R.-R.; Hou, Y.-X.; Liu, K.; Liu, Y.; Wang, W. Sterols from the Green Alga Ulva australis. Mar. Drugs 2017, 15, 299.

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