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Mar. Drugs 2017, 15(10), 251; doi:10.3390/md15100251

Brown Algae Padina sanctae-crucis Børgesen: A Potential Nutraceutical

1
Postgraduate Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-970, PB, Brazil
2
Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil
3
Postgraduate Program in Development and Technological Innovation in Medicines, Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-970, PB, Brazil
4
Department of Molecular Biology, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil
5
Department of Systematics and Ecology, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil
6
Center of R&D of Plant Genetic Resources, Agronomical Institute, CP28, Campinas 13001-970, SP, Brazil
*
Author to whom correspondence should be addressed.
Received: 1 July 2017 / Revised: 24 July 2017 / Accepted: 7 August 2017 / Published: 26 September 2017
(This article belongs to the Special Issue Nutraceuticals and Functional Foods)
View Full-Text   |   Download PDF [793 KB, uploaded 26 September 2017]   |  

Abstract

Padina sanctae-crucis Børgesen is distributed worldwide in tropical and subtropical seas; belongs to the Dictyotaceae family, and has proven to be an exceptional source of biologically active compounds. Four compounds were isolated and identified, namely: dolastane diterpene new for the genus Padina; phaeophytin and hidroxy-phaeophytin new for the family Dictyotaceae, and; mannitol first described in this species. Saturated fatty acids as compared to the percentages of unsaturated fatty acids were shown to be present in greater abundance. Palmitic and linolenic acid were the main saturated and unsaturated acids, respectively. Cytotoxic and antioxidant activities were evaluated using human erythrocytes. In vivo evaluations of acute toxicity and genotoxicity were performed in mice. Methanolic extract of P. sanctae-crucis presented antioxidant activity and did not induce cytotoxicity, genotoxicity or acute toxicity. Since Padina sanctae-crucis is already used as food, has essential fatty acids for the nutrition of mammals, does not present toxicity and has antioxidant activity, it can be considered as a potential nutraceutical. View Full-Text
Keywords: Dictyotaceae; dolastane diterpene; phaeophytin; mannitol; palmitic acid; linolenic acid; cytotoxicity; genotoxicity; acute toxicity Dictyotaceae; dolastane diterpene; phaeophytin; mannitol; palmitic acid; linolenic acid; cytotoxicity; genotoxicity; acute toxicity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Nogueira, R.B.S.S.; Tomaz, A.C.A.; Pessoa, D.R.; Xavier, A.L.; Pita, J.C.L.R.; Sobral, M.V.; Pontes, M.L.C.; Pessôa, H.L.F.; Diniz, M.F.F.M.; Miranda, G.E.C.; Vieira, M.A.R.; Marques, M.O.M.; Souza, M.F.V.; Cunha, E.V.L. Brown Algae Padina sanctae-crucis Børgesen: A Potential Nutraceutical. Mar. Drugs 2017, 15, 251.

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