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Mar. Drugs 2016, 14(9), 166; doi:10.3390/md14090166

R-Phycoerythrin Induces SGC-7901 Apoptosis by Arresting Cell Cycle at S Phase

1
Department of Pharmacy, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China
2
The Institute of Materia Medica, The Research Center of Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin 150076, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Peer B. Jacobson
Received: 2 August 2016 / Revised: 3 September 2016 / Accepted: 7 September 2016 / Published: 12 September 2016
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Abstract

R-Phycoerythrin (R-PE), one of the chemical constituents of red algae, could produce singlet oxygen upon excitation with the appropriate radiation and possibly be used in photodynamic therapy (PDT) for cancer. Documents reported that R-PE could inhibit cell proliferation in HepG2 and A549 cells, which was significative for cancer therapy. This is due to the fact that R-PE could kill cancer cells directly as well as by PDT. However, little is known about the cytotoxicity of R-PE to the SGC-7901 cell. In this study, it has been found that R-PE could inhibit SGC-7901 proliferation and induce cell apoptosis, which was achieved by arresting the SGC-7901 cell at S phase. CyclinA, CDK2 and CDC25A are proteins associated with the S phase, and it was found that R-PE could increase the expression of cyclin A protein and decrease the expression of CDK2 and CDC25A proteins. Thus, it was concluded that R-PE reduced the CDK2 protein activated through decreasing the CDC25A factor, which reduced the formation of Cyclin-CDK complex. The reduction of Cyclin-CDK complex made the SGC-7901 cells arrest at the S phase. Therefore, R-PE induced apoptosis by arresting the SGC-7901 cell at S phase was successful, which was achieved by the expression of the CDC25A protein, which reduced the CDK2 protein actived and the formation of Cyclin-CDK complex. View Full-Text
Keywords: R-phycoerythrin; apoptosis; cell cycle arrest; human gastric cancer; cell cycle-related protein R-phycoerythrin; apoptosis; cell cycle arrest; human gastric cancer; cell cycle-related protein
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MDPI and ACS Style

Tan, H.; Gao, S.; Zhuang, Y.; Dong, Y.; Guan, W.; Zhang, K.; Xu, J.; Cui, J. R-Phycoerythrin Induces SGC-7901 Apoptosis by Arresting Cell Cycle at S Phase. Mar. Drugs 2016, 14, 166.

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