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Mar. Drugs 2016, 14(8), 150; doi:10.3390/md14080150

Cubitanoids and Cembranoids from the Soft Coral Sinularia nanolobata

1
School of Pharmacy, China Medical University, Taichung 404, Taiwan
2
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
3
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
4
Ph.D. Program in Translational Medicine, College of Medicine and Ph.D. Program in Toxicology, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
5
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
6
Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan
7
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
8
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
9
Frontier Center for Ocean Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Received: 21 June 2016 / Revised: 19 July 2016 / Accepted: 29 July 2016 / Published: 9 August 2016
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Abstract

Two new cubitanoids, nanoculones A and B (1 and 2), and three new cembranoids, nanolobols A–C (35), as well as six known compounds, calyculone I (6), sinulariuol A (7), sinulariols C, D, H, and J (811), were isolated from the soft coral Sinularia nanolobata, collected off the coast of the eastern region of Taiwan. Their structures were elucidated on the basis of extensive spectroscopic analysis. Cytotoxicity of compounds 111 was evaluated. The nitric oxide (NO) inhibitory activity of selected compounds was further measured by assay of lipopolysaccharide (LPS)-stimulated NO production in activated RAW264.7 cells. The results showed that none of 111 exhibited cytotoxicity against the tested cancer cell lines, whereas compound 8 was found to significantly reduce NO production. View Full-Text
Keywords: Sinularia; cubitane; nanoculones A and B; nanolobols A–C Sinularia; cubitane; nanoculones A and B; nanolobols A–C
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MDPI and ACS Style

Chao, C.-H.; Wu, C.-Y.; Huang, C.-Y.; Wang, H.-C.; Dai, C.-F.; Wu, Y.-C.; Sheu, J.-H. Cubitanoids and Cembranoids from the Soft Coral Sinularia nanolobata. Mar. Drugs 2016, 14, 150.

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