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Mar. Drugs 2016, 14(7), 130; doi:10.3390/md14070130

Antiproliferative Scalarane-Based Metabolites from the Red Sea Sponge Hyrtios erectus

1
Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt
2
Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia
3
Pharmacology Department, Medical Division, National Research Centre, Giza 12622, Egypt
4
Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia
5
Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr el-Aini street, Cairo 11562, Egypt
6
Department of Clinical Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia
*
Author to whom correspondence should be addressed.
Academic Editor: Kirsten Benkendorff
Received: 13 April 2016 / Revised: 16 May 2016 / Accepted: 27 June 2016 / Published: 8 July 2016
(This article belongs to the Collection Bioactive Compounds from Marine Invertebrates)
View Full-Text   |   Download PDF [3010 KB, uploaded 11 July 2016]   |  

Abstract

Two new sesterterpenes analogs, namely, 12-acetoxy,16-epi-hyrtiolide (1) and 12β-acetoxy,16β-methoxy,20α-hydroxy-17-scalaren-19,20-olide (2), containing a scalarane-based framework along with seven previously reported scalarane-type sesterterpenes (39) have been isolated from the sponge Hyrtios erectus (order Dictyoceratida) collected from the Red Sea, Egypt. The structures of the isolated compounds were elucidated on the basis of their spectroscopic data and comparison with reported NMR data. Compounds 19 exhibited considerable antiproliferative activity against breast adenocarcinoma (MCF-7), colorectal carcinoma (HCT-116) and hepatocellular carcinoma cells (HepG2). Compounds 3, 5 and 9 were selected for subsequent investigations regarding their mechanism of cell death induction (differential apoptosis/necrosis assessment) and their influence on cell cycle distribution. View Full-Text
Keywords: Red Sea sponge; Hyrtios erectus; scalarane framework; cell based assay; antiproliferative activity Red Sea sponge; Hyrtios erectus; scalarane framework; cell based assay; antiproliferative activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Elhady, S.S.; Al-Abd, A.M.; El-Halawany, A.M.; Alahdal, A.M.; Hassanean, H.A.; Ahmed, S.A. Antiproliferative Scalarane-Based Metabolites from the Red Sea Sponge Hyrtios erectus. Mar. Drugs 2016, 14, 130.

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