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Mar. Drugs 2016, 14(7), 123; doi:10.3390/md14070123

Structural Features and Potent Antidepressant Effects of Total Sterols and β-sitosterol Extracted from Sargassum horneri

1
The Basic Medical College, Jilin Medical University, Jilin 132013, China
2
The Second Hospital, Jilin University, Changchun 130041, China
3
Food and Pharmacy College, Zhejiang Ocean University, Zhoushan 316022, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Peer B. Jacobson
Received: 6 May 2016 / Revised: 18 June 2016 / Accepted: 21 June 2016 / Published: 28 June 2016
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Abstract

The purified total sterols and β-sitosterol extracted from Sargassum horneri were evaluated for their antidepressant-like activity using the forced swim test (FST) and tail suspension test (TST) in mice. Total sterols and β-sitosterol significantly reduced the immobility time in the FST and TST. Total sterols were administered orally for 7 days at doses of 50, 100, and 200 mg/kg, and β-sitosterol was administered intraperitoneally at doses of 10, 20, and 30 mg/kg. β-sitosterol had no effect on locomotor activity in the open field test. In addition, total sterols and β-sitosterol significantly increased NE, 5-HT, and the metabolite 5-HIAA in the mouse brain, suggesting that the antidepressant-like activity may be mediated through these neurotransmitters. View Full-Text
Keywords: Sargassum horneri; sterols; β-sitosterol; FST; TST; monoamine neurotransmitters Sargassum horneri; sterols; β-sitosterol; FST; TST; monoamine neurotransmitters
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zhao, D.; Zheng, L.; Qi, L.; Wang, S.; Guan, L.; Xia, Y.; Cai, J. Structural Features and Potent Antidepressant Effects of Total Sterols and β-sitosterol Extracted from Sargassum horneri. Mar. Drugs 2016, 14, 123.

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