Pretrichodermamides D–F from a Marine Algicolous Fungus Penicillium sp. KMM 4672
AbstractThree new epidithiodiketopiperazines pretrichodermamides D–F (1–3), together with the known N-methylpretrichodermamide B (4) and pretrichodermamide С (5), were isolated from the lipophilic extract of the marine algae-derived fungus Penicillium sp. KMM 4672. The structures of compounds 1–5 were determined based on spectroscopic methods. The absolute configuration of pretrichodermamide D (1) was established by a combination of modified Mosher′s method, NOESY data, and biogenetic considerations. N-Methylpretrichodermamide B (5) showed strong cytotoxicity against 22Rv1 human prostate cancer cells resistant to androgen receptor targeted therapies. View Full-Text
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Yurchenko, A.N.; Smetanina, O.F.; Ivanets, E.V.; Kalinovsky, A.I.; Khudyakova, Y.V.; Kirichuk, N.N.; Popov, R.S.; Bokemeyer, C.; von Amsberg, G.; Chingizova, E.A.; Afiyatullov, S.S.; Dyshlovoy, S.A. Pretrichodermamides D–F from a Marine Algicolous Fungus Penicillium sp. KMM 4672. Mar. Drugs 2016, 14, 122.
Yurchenko AN, Smetanina OF, Ivanets EV, Kalinovsky AI, Khudyakova YV, Kirichuk NN, Popov RS, Bokemeyer C, von Amsberg G, Chingizova EA, Afiyatullov SS, Dyshlovoy SA. Pretrichodermamides D–F from a Marine Algicolous Fungus Penicillium sp. KMM 4672. Marine Drugs. 2016; 14(7):122.Chicago/Turabian Style
Yurchenko, Anton N.; Smetanina, Olga F.; Ivanets, Elena V.; Kalinovsky, Anatoly I.; Khudyakova, Yuliya V.; Kirichuk, Natalya N.; Popov, Roman S.; Bokemeyer, Carsten; von Amsberg, Gunhild; Chingizova, Ekaterina A.; Afiyatullov, Shamil S.; Dyshlovoy, Sergey A. 2016. "Pretrichodermamides D–F from a Marine Algicolous Fungus Penicillium sp. KMM 4672." Mar. Drugs 14, no. 7: 122.
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