The Effect of the Molecular Architecture on the Antioxidant Properties of Chitosan Gallate
AbstractTo elucidate the structure–antioxidant activity relationships of chitosan gallate (CG), a series of CG derivatives with different degrees of substitution (DS’s) and molecular weights (MWs) were synthesized from chitosan (CS) and gallic acid (GA) via a free radical graft reaction. A higher MW led to a lower DS of CG. The structures of CG were characterized by FT-IR and 1H NMR, and results showed that GA was mainly conjugated to the C-2 and C-6 positions of the CS chain. The antioxidant activity (the DPPH radical scavenging activity and reducing power) were enhanced with an increased DS and a decreased MW of CG. A correlation between antioxidant activities and the DS and MW of CG was also established. In addition, a suitable concentration (0~250 μg/mL) of CG with different MWs (32.78~489.32 kDa) and DS’s (0~92.89 mg·GAE/g CG) has no cytotoxicity. These results should provide a guideline to the application of CG derivatives in food or pharmacology industries. View Full-Text
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Wu, C.; Wang, L.; Fang, Z.; Hu, Y.; Chen, S.; Sugawara, T.; Ye, X. The Effect of the Molecular Architecture on the Antioxidant Properties of Chitosan Gallate. Mar. Drugs 2016, 14, 95.
Wu C, Wang L, Fang Z, Hu Y, Chen S, Sugawara T, Ye X. The Effect of the Molecular Architecture on the Antioxidant Properties of Chitosan Gallate. Marine Drugs. 2016; 14(5):95.Chicago/Turabian Style
Wu, Chunhua; Wang, Liping; Fang, Zhongxiang; Hu, Yaqin; Chen, Shiguo; Sugawara, Tatsuya; Ye, Xingqian. 2016. "The Effect of the Molecular Architecture on the Antioxidant Properties of Chitosan Gallate." Mar. Drugs 14, no. 5: 95.
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