Next Article in Journal
New Cyclic Lipopeptides of the Iturin Class Produced by Saltern-Derived Bacillus sp. KCB14S006
Previous Article in Journal
In Vitro Anticancer Activity of Phlorofucofuroeckol A via Upregulation of Activating Transcription Factor 3 against Human Colorectal Cancer Cells
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2016, 14(4), 70; doi:10.3390/md14040070

Influences of Fucoxanthin on Alveolar Bone Resorption in Induced Periodontitis in Rat Molars

1
Department of Periodontology, Faculty of Dentistry, Recep Tayyip Erdogan University, Rize 53100, Turkey
2
Department of Periodontology, Faculty of Dentistry, Ataturk University, Erzurum 25000, Turkey
3
Department of Histology and Embryology, Faculty of Veterinary Medicine, Ataturk University, Erzurum 25000, Turkey
4
Department of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, Erzurum 25000, Turkey
5
Department of Aquaculture, Faculty of Fisheries Sciences, Recep Tayyip Erdogan University, Rize 53100, Turkey
6
Department of Prosthodontics, Faculty of Dentistry, Recep Tayyip Erdogan University, Rize 53100, Turkey
*
Author to whom correspondence should be addressed.
Academic Editor: Keith B. Glaser
Received: 12 January 2016 / Revised: 16 March 2016 / Accepted: 24 March 2016 / Published: 30 March 2016
View Full-Text   |   Download PDF [1977 KB, uploaded 1 April 2016]   |  

Abstract

The aim of this study was to evaluate the effects of systemic fucoxanthin treatment on alveolar bone resorption in rats with periodontitis. Thirty rats were divided into control, experimental periodontitis (EP), and experimental periodontitis-fucoxanthin (EP-FUCO) groups. Periodontitis was induced by ligature for four weeks. After removal of the ligature, the rats in the EP-FUCO group were treated with a single dose of fucoxanthin (200 mg/kg bw) per day for 28 consecutive days. At the end of the study, all of the rats were euthanized and intracardiac blood and mandible tissue samples were obtained for biochemical, immunohistochemical, and histometric analyses. Fucoxanthin treatment resulted in a slight decrease in tumor necrosis factor-α, interleukin-1β, and interleukin-6 levels and a significant decrease in oxidative stress index. It was observed that fucoxanthin caused a significant reduction in receptor activator of nuclear factor kappa-β ligand (RANKL) levels and a statistically non-significant elevation in osteoprotegerin and bone-alkaline phosphatase levels. There were no significant differences in alveolar bone loss levels between the EP and EP-FUCO groups. This experimental study revealed that fucoxanthin provides a limited reduction in alveolar bone resorption in rats with periodontitis. One of the mechanisms underlying the mentioned limited effect might be related to the ability of fucoxanthin to inhibit oxidative stress-related RANKL-mediated osteoclastogenesis. View Full-Text
Keywords: animal model; antioxidant; experimental periodontitis; fucoxanthin; oxidative stress animal model; antioxidant; experimental periodontitis; fucoxanthin; oxidative stress
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kose, O.; Arabaci, T.; Yemenoglu, H.; Kara, A.; Ozkanlar, S.; Kayis, S.; Duymus, Z.Y. Influences of Fucoxanthin on Alveolar Bone Resorption in Induced Periodontitis in Rat Molars. Mar. Drugs 2016, 14, 70.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top