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Mar. Drugs 2016, 14(4), 72; doi:10.3390/md14040072

New Cyclic Lipopeptides of the Iturin Class Produced by Saltern-Derived Bacillus sp. KCB14S006

1
Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 363-883, Korea
2
University of Science and Technology (UST), Daejeon 305-333, Korea
3
Chemical Biology Research Group, RIKEN Center for Sustainable Research Science, Saitama 351-0198, Japan
4
Korean Collection for Type Cultures, Korea Research Institute of Bioscience and Biotechnology, Jeongeup 56212, Korea
5
College of Pharmacy, Wonkwang University, Iksan 570-749, Korea
6
RIKEN-KRIBB Joint Research Unit, RIKRN Global Research Cluster, Saitama 351-0198, Japan
*
Authors to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Received: 15 February 2016 / Revised: 24 March 2016 / Accepted: 28 March 2016 / Published: 2 April 2016
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Abstract

Salterns, one of the most extreme natural hypersaline environments, are a rich source of halophilic and halotolerant microorganisms, but they remain largely underexplored ecological niches in the discovery of bioactive secondary metabolites. In continued efforts to investigate the metabolic potential of microbial populations from chemically underexplored sites, three new lipopeptides named iturin F1, iturin F2 and iturin A9 (13), along with iturin A8 (4), were isolated from Bacillus sp. KCB14S006 derived from a saltern. The structures of the isolated compounds were established by 1D-, 2D-NMR and HR-ESIMS, and their absolute configurations were determined by applying advanced Marfey’s method and CD spectroscopy. All isolates exhibited significant antifungal activities against various pathogenic fungi and moderate cytotoxic activities toward HeLa and srcts-NRK cell lines. Moreover, in an in vitro enzymatic assay, compound 4 showed a significant inhibitory activity against indoleamine 2,3-dioxygenase. View Full-Text
Keywords: saltern-derived bacteria; iturins; antifungal; cytotoxic; indoleamine-2,3-dioxygenase saltern-derived bacteria; iturins; antifungal; cytotoxic; indoleamine-2,3-dioxygenase
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Son, S.; Ko, S.-K.; Jang, M.; Kim, J.W.; Kim, G.S.; Lee, J.K.; Jeon, E.S.; Futamura, Y.; Ryoo, I.-J.; Lee, J.-S.; Oh, H.; Hong, Y.-S.; Kim, B.Y.; Takahashi, S.; Osada, H.; Jang, J.-H.; Ahn, J.S. New Cyclic Lipopeptides of the Iturin Class Produced by Saltern-Derived Bacillus sp. KCB14S006. Mar. Drugs 2016, 14, 72.

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