New Cyclic Lipopeptides of the Iturin Class Produced by Saltern-Derived Bacillus sp. KCB14S006
AbstractSalterns, one of the most extreme natural hypersaline environments, are a rich source of halophilic and halotolerant microorganisms, but they remain largely underexplored ecological niches in the discovery of bioactive secondary metabolites. In continued efforts to investigate the metabolic potential of microbial populations from chemically underexplored sites, three new lipopeptides named iturin F1, iturin F2 and iturin A9 (1–3), along with iturin A8 (4), were isolated from Bacillus sp. KCB14S006 derived from a saltern. The structures of the isolated compounds were established by 1D-, 2D-NMR and HR-ESIMS, and their absolute configurations were determined by applying advanced Marfey’s method and CD spectroscopy. All isolates exhibited significant antifungal activities against various pathogenic fungi and moderate cytotoxic activities toward HeLa and srcts-NRK cell lines. Moreover, in an in vitro enzymatic assay, compound 4 showed a significant inhibitory activity against indoleamine 2,3-dioxygenase. View Full-Text
- Supplementary File 1:
PDF-Document (PDF, 2690 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Son, S.; Ko, S.-K.; Jang, M.; Kim, J.W.; Kim, G.S.; Lee, J.K.; Jeon, E.S.; Futamura, Y.; Ryoo, I.-J.; Lee, J.-S.; Oh, H.; Hong, Y.-S.; Kim, B.Y.; Takahashi, S.; Osada, H.; Jang, J.-H.; Ahn, J.S. New Cyclic Lipopeptides of the Iturin Class Produced by Saltern-Derived Bacillus sp. KCB14S006. Mar. Drugs 2016, 14, 72.
Son S, Ko S-K, Jang M, Kim JW, Kim GS, Lee JK, Jeon ES, Futamura Y, Ryoo I-J, Lee J-S, Oh H, Hong Y-S, Kim BY, Takahashi S, Osada H, Jang J-H, Ahn JS. New Cyclic Lipopeptides of the Iturin Class Produced by Saltern-Derived Bacillus sp. KCB14S006. Marine Drugs. 2016; 14(4):72.Chicago/Turabian Style
Son, Sangkeun; Ko, Sung-Kyun; Jang, Mina; Kim, Jong W.; Kim, Gil S.; Lee, Jae K.; Jeon, Eun S.; Futamura, Yushi; Ryoo, In-Ja; Lee, Jung-Sook; Oh, Hyuncheol; Hong, Young-Soo; Kim, Bo Y.; Takahashi, Shunji; Osada, Hiroyuki; Jang, Jae-Hyuk; Ahn, Jong S. 2016. "New Cyclic Lipopeptides of the Iturin Class Produced by Saltern-Derived Bacillus sp. KCB14S006." Mar. Drugs 14, no. 4: 72.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.