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Mar. Drugs 2016, 14(3), 51; doi:10.3390/md14030051

Nigrodiquinone A, a Hydroanthraquinone Dimer Containing a Rare C-9–C-7′ Linkage from a Zoanthid-Derived Nigrospora sp. Fungus

1
State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China
2
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
3
College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China
4
Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266200, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Received: 27 January 2016 / Revised: 29 February 2016 / Accepted: 4 March 2016 / Published: 9 March 2016
View Full-Text   |   Download PDF [891 KB, uploaded 9 March 2016]   |  

Abstract

One new hydroanthraquinone dimer with a rare C-9–C-7′ linkage, nigrodiquinone A (1), and four known anthraquinone monomers 2–5, were isolated from a fungus Nigrospora sp. obtained from the zoanthid Palythoa haddoni collected in the South China Sea. The structure of 1 was established through extensive NMR spectroscopy, and the absolute configuration was elucidated by comparing computed electronic circular dichroism (ECD) and optical rotations (OR) with experimental results. All the compounds were evaluated for antiviral activity, and 1 was also evaluated for antibacterial activity. Compound 4 displayed mild antiviral activity against coxsackie virus (Cox-B3) with the IC50 value of 93.7 μM, and 5 showed an IC50 value of 74.0 μM against respiratory syncytial virus (RSV). View Full-Text
Keywords: zoanthid Palythoa haddoni; Nigrospora sp.; hydroanthraquinone dimer; antibacterial; antiviral zoanthid Palythoa haddoni; Nigrospora sp.; hydroanthraquinone dimer; antibacterial; antiviral
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Xu, W.-F.; Hou, X.-M.; Yang, K.-L.; Cao, F.; Yang, R.-Y.; Wang, C.-Y.; Shao, C.-L. Nigrodiquinone A, a Hydroanthraquinone Dimer Containing a Rare C-9–C-7′ Linkage from a Zoanthid-Derived Nigrospora sp. Fungus. Mar. Drugs 2016, 14, 51.

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