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Mar. Drugs 2016, 14(3), 44; doi:10.3390/md14030044

Eutypenoids A–C: Novel Pimarane Diterpenoids from the Arctic Fungus Eutypella sp. D-1

1
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China
2
Shanghai Institute of Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China
3
Department of Biochemistry and Molecular Biology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Received: 14 January 2016 / Revised: 14 February 2016 / Accepted: 15 February 2016 / Published: 7 March 2016
View Full-Text   |   Download PDF [1830 KB, uploaded 7 March 2016]   |  

Abstract

Eutypenoids A–C (13), pimarane diterpenoid alkaloid and two ring A rearranged pimarane diterpenoids, were isolated from the culture of Eutypella sp. D-1 obtained from high-latitude soil of the Arctic. Their structures, including absolute configurations, were authenticated on the basis of the mass spectroscopy (MS), nuclear magnetic resonance (NMR), X-ray crystallography, and electronic circular dichroism (ECD) analysis. The immunosuppressive effects of eutypenoids A–C (13) were studied using a ConA-induced splenocyte proliferation model, which suggested that 2 exhibited potent immunosuppressive activities. View Full-Text
Keywords: eutypenoid; novel pimarane diterpenes; Eutypella; Arctic fungi; immunosuppressive effect eutypenoid; novel pimarane diterpenes; Eutypella; Arctic fungi; immunosuppressive effect
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MDPI and ACS Style

Zhang, L.-Q.; Chen, X.-C.; Chen, Z.-Q.; Wang, G.-M.; Zhu, S.-G.; Yang, Y.-F.; Chen, K.-X.; Liu, X.-Y.; Li, Y.-M. Eutypenoids A–C: Novel Pimarane Diterpenoids from the Arctic Fungus Eutypella sp. D-1. Mar. Drugs 2016, 14, 44.

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