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Mar. Drugs 2016, 14(2), 29; doi:10.3390/md14020029

Strategies to Maximize the Potential of Marine Biomaterials as a Platform for Cell Therapy

1,2
and
1,2,*
1
Pharmaceutical Formulation Design Laboratory, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea
2
Bio-Integration Research Center for Nutra-Pharmaceutical Epigenetics, Chung-Ang University, Seoul 156-756, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Paola Laurienzo
Received: 27 November 2015 / Revised: 15 January 2016 / Accepted: 19 January 2016 / Published: 26 January 2016
View Full-Text   |   Download PDF [2220 KB, uploaded 26 January 2016]   |  

Abstract

Marine biopolymers have been explored as a promising cell therapy system for efficient cell delivery and tissue engineering. However, the marine biomaterial-based systems themselves have exhibited limited performance in terms of maintenance of cell viability and functions, promotion of cell proliferation and differentiation as well as cell delivery efficiency. Thus, numerous novel strategies have been devised to improve cell therapy outcomes. The strategies include optimization of physical and biochemical properties, provision of stimuli-responsive functions, and design of platforms for efficient cell delivery and tissue engineering. These approaches have demonstrated substantial improvement of therapeutic outcomes in a variety of research settings. In this review, therefore, research progress made with marine biomaterials as a platform for cell therapy is reported along with current research directions to further advance cell therapies as a tool to cure incurable diseases. View Full-Text
Keywords: marine biomaterials; cell therapy; tissue engineering; optimization; stimuli-responsive systems; delivery systems marine biomaterials; cell therapy; tissue engineering; optimization; stimuli-responsive systems; delivery systems
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kim, H.; Lee, J. Strategies to Maximize the Potential of Marine Biomaterials as a Platform for Cell Therapy. Mar. Drugs 2016, 14, 29.

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