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Mar. Drugs 2016, 14(2), 26; doi:10.3390/md14020026

New Perspectives in the Chemistry of Marine Pyridoacridine Alkaloids

Department of Pharmacy—Center for Drug Research, Ludwig-Maximilians University, Butenandtstr. 5-13, 81377 Munich, Germany
Dedicated to Prof. Dr. Gunther Seitz, Marburg, on the occasion of his 80th birthday
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Author to whom correspondence should be addressed.
Academic Editor: Patrizia Diana
Received: 28 November 2015 / Revised: 9 January 2016 / Accepted: 15 January 2016 / Published: 26 January 2016
(This article belongs to the Special Issue Synthesis of Antitumor Marine Alkaloids and Related Analogues)

Abstract

Secondary metabolites from marine organisms are a rich source of novel leads for drug development. Among these natural products, polycyclic aromatic alkaloids of the pyridoacridine type have attracted the highest attention as lead compounds for the development of novel anti-cancer and anti-infective drugs. Numerous sophisticated total syntheses of pyridoacridine alkaloids have been worked out, and many of them have also been extended to the synthesis of libraries of analogues of the alkaloids. This review summarizes the progress in the chemistry of pyridoacridine alkaloids that was made in the last one-and-a-half decades. View Full-Text
Keywords: marine alkaloids; pyridoacridines; total synthesis marine alkaloids; pyridoacridines; total synthesis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Plodek, A.; Bracher, F. New Perspectives in the Chemistry of Marine Pyridoacridine Alkaloids. Mar. Drugs 2016, 14, 26.

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