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Mar. Drugs 2016, 14(2), 20; doi:10.3390/md14020020

Larvicidal Potential of the Halogenated Sesquiterpene (+)-Obtusol, Isolated from the Alga Laurencia dendroidea J. Agardh (Ceramiales: Rhodomelaceae), against the Dengue Vector Mosquito Aedes aegypti (Linnaeus) (Diptera: Culicidae)

1
Laboratório Integrado de Bioquímica Hatisaburo Masuda (LIBHM); Núcleo em Pesquisas Ecológicas e Desenvolvimento Sócio-Ambiental de Macaé (NUPEM), Universidade Federal do Rio de Janeiro, Macaé, Rio de Janeiro 27965-045, Brazil
2
Grupo de Produtos Naturais de Organismos Aquáticos (GPNOA), Núcleo em Ecologia e Desenvolvimento Sócio-Ambiental de Macaé (NUPEM), Universidade Federal do Rio de Janeiro, Macaé, Rio de Janeiro 27965-045, Brazil
3
Laboratório Integrado de Ciências Morfofuncionais (LICMF), Núcleo em Ecologia e Desenvolvimento Sócio-Ambiental de Macaé (NUPEM), Universidade Federal do Rio de Janeiro, Macaé, Rio de Janeiro 27965-045, Brazil
4
Laboratório de Entomologia e Fitopatologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Rio de Janeiro 28013-602, Brazil
5
Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, (INCT-EM), Rio de Janeiro 21941-590, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Peer B. Jacobson
Received: 20 November 2015 / Revised: 5 January 2016 / Accepted: 5 January 2016 / Published: 25 January 2016
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Abstract

Dengue is considered a serious public health problem in many tropical regions of the world including Brazil. At the moment, there is no viable alternative to reduce dengue infections other than controlling the insect vector, Aedes aegypti Linnaeus. In the continuing search for new sources of chemicals targeted at vector control, natural products are a promising alternative to synthetic pesticides. In our work, we investigated the toxicity of a bioactive compound extracted from the red alga Laurencia dendroidea J. Agardh. The initial results demonstrated that crude extracts, at a concentration of 5 ppm, caused pronounced mortality of second instar A. aegypti larvae. Two molecules, identified as (−)-elatol and (+)-obtusol were subsequently isolated from crude extract and further evaluated. Assays with (−)-elatol showed moderate larvicidal activity, whereas (+)-obtusol presented higher toxic activity than (−)-elatol, with a LC50 value of 3.5 ppm. Histological analysis of the larvae exposed to (+)-obtusol revealed damage to the intestinal epithelium. Moreover, (+)-obtusol-treated larvae incubated with 2 µM CM-H2DCFDA showed the presence of reactive oxygen species, leading us to suggest that epithelial damage might be related to redox imbalance. These results demonstrate the potential of (+)-obtusol as a larvicide for use against A. aegypti and the possible mode of action of this compound. View Full-Text
Keywords: Laurencia dendroidea; Aedes aegypti; larvicide; sesquiterpenes; (+)-obtusol; (−)-elatol; oxidative stress Laurencia dendroidea; Aedes aegypti; larvicide; sesquiterpenes; (+)-obtusol; (−)-elatol; oxidative stress
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MDPI and ACS Style

Salvador-Neto, O.; Gomes, S.A.; Soares, A.R.; Machado, F.L.S.; Samuels, R.I.; Nunes da Fonseca, R.; Souza-Menezes, J.; Moraes, J.L.C.; Campos, E.; Mury, F.B.; Silva, J.R. Larvicidal Potential of the Halogenated Sesquiterpene (+)-Obtusol, Isolated from the Alga Laurencia dendroidea J. Agardh (Ceramiales: Rhodomelaceae), against the Dengue Vector Mosquito Aedes aegypti (Linnaeus) (Diptera: Culicidae). Mar. Drugs 2016, 14, 20.

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