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Mar. Drugs 2016, 14(1), 16; doi:10.3390/md14010016

Marine Isonitriles and Their Related Compounds

Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55128 Mainz, Germany
Both authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Received: 30 November 2015 / Revised: 16 December 2015 / Accepted: 23 December 2015 / Published: 14 January 2016


Marine isonitriles represent the largest group of natural products carrying the remarkable isocyanide moiety. Together with marine isothiocyanates and formamides, which originate from the same biosynthetic pathways, they offer diverse biological activities and in spite of their exotic nature they may constitute potential lead structures for pharmaceutical development. Among other biological activities, several marine isonitriles show antimalarial, antitubercular, antifouling and antiplasmodial effects. In contrast to terrestrial isonitriles, which are mostly derived from α-amino acids, the vast majority of marine representatives are of terpenoid origin. An overview of all known marine isonitriles and their congeners will be given and their biological and chemical aspects will be discussed. View Full-Text
Keywords: isonitriles; marine natural products; terpenes; isothiocyanates; formamides; antibiotics; carbonimidic dichlorides; malaria isonitriles; marine natural products; terpenes; isothiocyanates; formamides; antibiotics; carbonimidic dichlorides; malaria

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Emsermann, J.; Kauhl, U.; Opatz, T. Marine Isonitriles and Their Related Compounds. Mar. Drugs 2016, 14, 16.

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