Five New Cytotoxic Metabolites from the Marine Fungus Neosartorya pseudofischeri
AbstractThe marine fungus Neosartorya pseudofischeri was isolated from Acanthaster planci from the South China Sea. In a preliminary bioactivity screening, the crude methanol extract of the fungal mycelia showed significant inhibitory activity against the Sf9 cell line from the fall armyworm Spodoptera frugiperda. Five novel compounds, including 5-olefin phenylpyropene A (1), 13-dehydroxylpyripyropene A (4), deacetylsesquiterpene (7), 5-formyl-6-hydroxy-8-isopropyl-2- naphthoic acid (9) and 6,8-dihydroxy-3-((1E,3E)-penta-1,3-dien-1-yl)isochroman-1-one (10), together with eleven known compounds, phenylpyropene A (2) and C (3), pyripyropene A (5), 7-deacetylpyripyropene A (6), (1S,2R,4aR,5R,8R,8aR)-1,8a-dihydroxy-2-acetoxy-3,8-dimethyl-5- (prop-1-en-2-yl)-1,2,4a, 5,6,7,8,8a-octahydronaphthalene (8), isochaetominine C (11), trichodermamide A (12), indolyl-3-acetic acid methyl ester (13), 1-acetyl-β-carboline (14), 1,2,3,4-tetrahydro-6-hydroxyl-2-methyl-l,3,4-trioxopyrazino[l,2-a]-indole (15) and fumiquinazoline F (16), were obtained. The structures of these compounds were determined mainly by MS and NMR data. The absolute configuration of 9 was assigned by the single-crystal X-ray diffraction studies. Compounds 1–11 and 15 showed significant cytotoxicity against the Sf9 cells from S. frugiperda. View Full-Text
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Lan, W.-J.; Fu, S.-J.; Xu, M.-Y.; Liang, W.-L.; Lam, C.-K.; Zhong, G.-H.; Xu, J.; Yang, D.-P.; Li, H.-J. Five New Cytotoxic Metabolites from the Marine Fungus Neosartorya pseudofischeri. Mar. Drugs 2016, 14, 18.
Lan W-J, Fu S-J, Xu M-Y, Liang W-L, Lam C-K, Zhong G-H, Xu J, Yang D-P, Li H-J. Five New Cytotoxic Metabolites from the Marine Fungus Neosartorya pseudofischeri. Marine Drugs. 2016; 14(1):18.Chicago/Turabian Style
Lan, Wen-Jian; Fu, Sheng-Jiao; Xu, Meng-Yang; Liang, Wan-Ling; Lam, Chi-Keung; Zhong, Guo-Hua; Xu, Jun; Yang, De-Po; Li, Hou-Jin. 2016. "Five New Cytotoxic Metabolites from the Marine Fungus Neosartorya pseudofischeri." Mar. Drugs 14, no. 1: 18.
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