Next Article in Journal
A Pimarane Diterpene and Cytotoxic Angucyclines from a Marine-Derived Micromonospora sp. in Vietnam’s East Sea
Previous Article in Journal
Synthesis and Antiplasmodial Evaluation of Analogues Based on the Tricyclic Core of Thiaplakortones A–D
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2015, 13(9), 5796-5814; doi:10.3390/md13095796

Nitrogen-Containing Diterpenoids, Sesquiterpenoids, and Nor-Diterpenoids from Cespitularia taeniata

1
School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan
2
Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan
3
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
4
National Research Institute of Chinese Medicine, Taipei 112, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Received: 13 August 2015 / Revised: 7 September 2015 / Accepted: 9 September 2015 / Published: 15 September 2015
View Full-Text   |   Download PDF [566 KB, uploaded 15 September 2015]   |  

Abstract

Two new nitrogen-containing verticillene diterpenoids, cespilamides A and B (1 and 2), three new nitrogen-containing sesquiterpenoids, cespilamides C–E (35), and five new norverticillene and verticillene diterpenoids, cespitaenins A–E (610), were isolated from the Taiwanese soft coral Cespitularia taeniata. Compound 1 possesses an unusual oxazo ring system at C-10 while compound 2 displays an unprecedented C–C bond cleavage between C-10 and C-11 with an N-ethylphenyl group at C-10. Biogenetic pathways of 1 and 2 are proposed. The absolute configuration of 1 was confirmed by Mosher’s method and molecular mechanics calculations (MM2). The cytotoxicities of compounds 110 were evaluated against a small panel of human cancer cell lines. View Full-Text
Keywords: Cespitularia taeniata; verticillene diterpenoids; cytotoxicity Cespitularia taeniata; verticillene diterpenoids; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Wang, S.-S.; Cheng, Y.-B.; Lin, Y.-C.; Liaw, C.-C.; Chang, J.-Y.; Kuo, Y.-H.; Shen, Y.-C. Nitrogen-Containing Diterpenoids, Sesquiterpenoids, and Nor-Diterpenoids from Cespitularia taeniata. Mar. Drugs 2015, 13, 5796-5814.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top