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Mar. Drugs 2015, 13(8), 4967-4984; doi:10.3390/md13084967

Signal Transducers and Activators of Transcription (STAT) Regulatory Networks in Marine Organisms: From Physiological Observations towards Marine Drug Discovery

1
Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 151-742, Korea
2
Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hôpital Kirchberg 9, rue Edward Steichen, Luxembourg 2540, Luxembourg
*
Author to whom correspondence should be addressed.
Academic Editor: Anake Kijjoa
Received: 22 May 2015 / Revised: 30 July 2015 / Accepted: 31 July 2015 / Published: 7 August 2015
View Full-Text   |   Download PDF [909 KB, uploaded 7 August 2015]   |  

Abstract

Part of our ocean’s richness comes from its extensive history of supporting life, resulting in a highly diverse ecological system. To date, over 250,000 species of marine organisms have been identified, but it is speculated that the actual number of marine species exceeds one million, including several hundreds of millions of species of marine microorganisms. Past studies suggest that approximately 70% of all deep-sea microorganisms, gorgonians, and sea sponges produce secondary metabolites with anti-cancer activities. Recently, novel FDA-approved drugs derived from marine sponges have been shown to reduce metastatic breast cancer, malignant lymphoma, and Hodgkin’s disease. Despite the fact that many marine natural products have been shown to possess a good inhibition potential against most of the cancer-related cell signaling pathways, only a few marine natural products have been shown to target JAK/STAT signaling. In the present paper, we describe the JAK/STAT signaling pathways found in marine organisms, before elaborating on the recent advances in the field of STAT inhibition by marine natural products and the potential application in anti-cancer drug discovery. View Full-Text
Keywords: anti-cancer; drug discovery; JAK/STAT signaling anti-cancer; drug discovery; JAK/STAT signaling
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lee, J.-Y.; Orlikova, B.; Diederich, M. Signal Transducers and Activators of Transcription (STAT) Regulatory Networks in Marine Organisms: From Physiological Observations towards Marine Drug Discovery. Mar. Drugs 2015, 13, 4967-4984.

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