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Mar. Drugs 2015, 13(7), 4418-4435; doi:10.3390/md13074418

Four New Sulfated Polar Steroids from the Far Eastern Starfish Leptasterias ochotensis: Structures and Activities

G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia
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Academic Editor: Valeria Costantino
Received: 6 May 2015 / Revised: 1 July 2015 / Accepted: 9 July 2015 / Published: 16 July 2015
(This article belongs to the Special Issue Marine Secondary Metabolites)
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Abstract

Three new sulfated steroid monoglycosides, leptaochotensosides A–C (13), and a new sulfated polyhydroxylated steroid (4) were isolated from the alcoholic extract of the Far Eastern starfish Leptasterias ochotensis. The structures of compounds 14 were established by extensive nuclear magnetic resonance (NMR) and electrospray ionization mass spectrometry (ESIMS) analyses and chemical transformations. Although the isolated compounds did not show any apparent cytotoxicity against melanoma RPMI-7951 and breast cancer T-47D cell lines, leptaochotensoside A (1) demonstrated inhibition of T-47D cell colony formation in a soft agar clonogenic assay at nontoxic doses. In addition, this compound decreased the epidermal growth factor (EGF)-induced colony formation of mouse epidermal JB6 Cl41 cells. The cancer preventive action of 1 is realized through regulation of mitogen-activated protein kinase (MAPK) signaling pathway. View Full-Text
Keywords: steroids; sulfated steroids; glycosides; starfish; Leptasterias ochotensis; cytotoxicity; neoplastic cell transformation; MAPK steroids; sulfated steroids; glycosides; starfish; Leptasterias ochotensis; cytotoxicity; neoplastic cell transformation; MAPK
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Malyarenko, T.V.; Malyarenko (Vishchuk), O.S.; Ivanchina, N.V.; Kalinovsky, A.I.; Popov, R.S.; Kicha, A.A. Four New Sulfated Polar Steroids from the Far Eastern Starfish Leptasterias ochotensis: Structures and Activities. Mar. Drugs 2015, 13, 4418-4435.

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