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Mar. Drugs 2015, 13(5), 2757-2769; doi:10.3390/md13052757

Eunicellin-Based Diterpenoids, Hirsutalins S–V, from the Formosan Soft Coral Cladiella hirsuta

1
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
2
Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine, and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan
3
Department of Cosmetic Science and Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
4
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
5
Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan
6
Department of Life Science and Institute of Biotechnology and Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
7
Frontier Center for Ocean Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan
8
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
9
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
10
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Received: 24 March 2015 / Revised: 20 April 2015 / Accepted: 20 April 2015 / Published: 30 April 2015
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Abstract

Four new eunicellin-type hirsutalins S–V (14), along with a known compound (–)-6α-hydroxy polyanthellin A (5), were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxity of compounds 15 against the proliferation of a limited panel of cancer cell lines was measured. Anti-inflammatory activity of compounds 15 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/ CB-induced human neutrophils. View Full-Text
Keywords: soft coral; Cladiella hirsuta; eunicellins; cytotoxic activity; anti-inflammatory activity soft coral; Cladiella hirsuta; eunicellins; cytotoxic activity; anti-inflammatory activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Huang, T.-Z.; Chen, B.-W.; Huang, C.-Y.; Hwang, T.-L.; Uvarani, C.; Dai, C.-F.; Sung, P.-J.; Su, J.-H.; Sheu, J.-H. Eunicellin-Based Diterpenoids, Hirsutalins S–V, from the Formosan Soft Coral Cladiella hirsuta. Mar. Drugs 2015, 13, 2757-2769.

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