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Mar. Drugs 2015, 13(5), 2617-2628; doi:10.3390/md13052617

Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp.

1
Laboratoire Molécules de Communication et Adaptation des Micro-organismes, CNRS/MNHN 7245, Muséum National d'Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France
2
School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
3
ManRos Therapeutics, Perharidy Research Center, 29680 Roscoff, France
These authors contributed equally to this paper.
*
Author to whom correspondence should be addressed.
Academic Editor: Christian Peifer
Received: 3 March 2015 / Revised: 2 April 2015 / Accepted: 3 April 2015 / Published: 28 April 2015
(This article belongs to the Special Issue Marine Compounds as Protein Kinase Inhibitors)
View Full-Text   |   Download PDF [798 KB, uploaded 28 April 2015]   |  

Abstract

Seven new adociaquinone derivatives, xestoadociaquinones A (1a), B (1b), 14-carboxy-xestoquinol sulfate (2) and xestoadociaminals A–D (3a, 3c, 4a, 4c), together with seven known compounds (511) were isolated from an Indonesian marine sponge Xestospongia sp. Their structures were elucidated by extensive 1D and 2D NMR and mass spectrometric data. All the compounds were evaluated for their potential inhibitory activity against eight different protein kinases involved in cell proliferation, cancer, diabetes and neurodegenerative disorders as well as for their antioxidant and antibacterial activities. View Full-Text
Keywords: kinase inhibitor; adociaquinone; xestoadociaquinone; 14-carboxy-xestoquinol sulfate; xestoadociaminal; Xestospongia sp. kinase inhibitor; adociaquinone; xestoadociaquinone; 14-carboxy-xestoquinol sulfate; xestoadociaminal; Xestospongia sp.
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

He, F.; Mai, L.H.; Longeon, A.; Copp, B.R.; Loaëc, N.; Bescond, A.; Meijer, L.; Bourguet-Kondracki, M.-L. Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp.. Mar. Drugs 2015, 13, 2617-2628.

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