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Mar. Drugs 2015, 13(4), 2085-2104; doi:10.3390/md13042085

Studies toward the Total Synthesis of Itralamide B and Biological Evaluation of Its Structural Analogs

1
School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013, China
2
Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, University Town of Shenzhen, Xili, Nanshan District, Shenzhen 518055, China
3
Department of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
*
Authors to whom correspondence should be addressed.
Academic Editor: Peter Duggan
Received: 8 February 2015 / Revised: 17 March 2015 / Accepted: 30 March 2015 / Published: 13 April 2015
(This article belongs to the Special Issue Marine Peptides and Their Mimetics)
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Abstract

Itralamides A and B were isolated from the lipophilic extract of Lyngbya majuscula collected from the eastern Caribbean. Itralamide B (1) showed cytotoxic activity towards human embryonic kidney cells (HEK293, IC50 = 6 μM). Preliminary studies disapproved the proposed stereochemistry of itralamide. In this paper, we will provide a full account of the total synthesis of four stereoisomers of itralamide B and the results derived from biological tests of these structural congeners. View Full-Text
Keywords: itralamide B; cyclodepsipeptide; total synthesis; structural analogs; biological study itralamide B; cyclodepsipeptide; total synthesis; structural analogs; biological study
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wang, X.; Lv, C.; Feng, J.; Tang, L.; Wang, Z.; Liu, Y.; Meng, Y.; Ye, T.; Xu, Z. Studies toward the Total Synthesis of Itralamide B and Biological Evaluation of Its Structural Analogs. Mar. Drugs 2015, 13, 2085-2104.

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