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Mar. Drugs 2015, 13(4), 1785-1797; doi:10.3390/md13041785

First Evidence that Ecklonia cava-Derived Dieckol Attenuates MCF-7 Human Breast Carcinoma Cell Migration

1
Division of Food Bio Science, College of Biomedical and Health Sciences, Konkuk University, Chungju 380-701, Korea
2
Korea Nokyong Research Center, Konkuk University, Chungju 380-701, Korea
3
Department of Biotechnology, Konkuk University, Chungju 380-701, Korea
4
Division of Sport Science, Konkuk University, Chungju, 380-701, Korea
5
Department of Marine Life Science, Jeju National University, Jeju 690-756, Korea
*
Author to whom correspondence should be addressed.
Academic Editors: Sergey A. Dyshlovoy and Friedemann Honecker
Received: 1 February 2015 / Revised: 9 March 2015 / Accepted: 18 March 2015 / Published: 30 March 2015
(This article belongs to the Collection Marine Compounds and Cancer)
View Full-Text   |   Download PDF [677 KB, uploaded 30 March 2015]   |  

Abstract

We investigated the effect of Ecklonia cava (E. cava)-derived dieckol on movement behavior and the expression of migration-related genes in MCF-7 human breast cancer cell. Phlorotannins (e.g., dieckol, 6,6′-biecko, and 2,7″-phloroglucinol-6,6′-bieckol) were purified from E. cava by using centrifugal partition chromatography. Among the phlorotannins, we found that dieckol inhibited breast cancer cell the most and was selected for further study. Radius™-well was used to assess cell migration, and dieckol (1–100 µM) was found to suppress breast cancer cell movement. Metastasis-related gene expressions were evaluated by RT-PCR and Western blot analysis. In addition, dieckol inhibited the expression of migration-related genes such as matrix metalloproteinase (MMP)-9 and vascular endothelial growth factor (VEGF). On the other hand, it stimulated the expression of tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2. These results suggest that dieckol exerts anti-breast cancer activity via the regulation of the expressions of metastasis-related genes, and this is the first report on the anti-breast cancer effect of dieckol. View Full-Text
Keywords: Ecklonia cava; phlorotannins; dieckol; breast cancer; migration Ecklonia cava; phlorotannins; dieckol; breast cancer; migration
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kim, E.-K.; Tang, Y.; Kim, Y.-S.; Hwang, J.-W.; Choi, E.-J.; Lee, J.-H.; Lee, S.-H.; Jeon, Y.-J.; Park, P.-J. First Evidence that Ecklonia cava-Derived Dieckol Attenuates MCF-7 Human Breast Carcinoma Cell Migration. Mar. Drugs 2015, 13, 1785-1797.

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