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Mar. Drugs 2015, 13(10), 6247-6258; doi:10.3390/md13106247

Mycemycins A–E, New Dibenzoxazepinones Isolated from Two Different Streptomycetes

1,†
,
1,2,†
,
3
and
1,*
1
State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
2
University of Chinese Academy of Sciences, Beijing 100049, China
3
Analytical and Testing Center, Beijing University of Chemical Technology, Beijing 100029, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Received: 25 July 2015 / Revised: 17 September 2015 / Accepted: 18 September 2015 / Published: 30 September 2015
View Full-Text   |   Download PDF [314 KB, uploaded 30 September 2015]   |  

Abstract

Five new dibenzoxazepinone derivatives, mycemycins A–E (15), were isolated from the ethanol extracts of mycelia of two different streptomycetes. 1 and 2 were isolated from an acidic red soil-derived strain, Streptomyces sp. FXJ1.235, and 35 from a gntR gene-disrupted deep-sea strain named Streptomyces olivaceus FXJ8.012Δ1741. The structures of mycemycins were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR techniques. View Full-Text
Keywords: mycemycin; dibenzoxazepinone; deep-sea; Streptomyces; gene disruption mycemycin; dibenzoxazepinone; deep-sea; Streptomyces; gene disruption
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Liu, N.; Song, F.; Shang, F.; Huang, Y. Mycemycins A–E, New Dibenzoxazepinones Isolated from Two Different Streptomycetes. Mar. Drugs 2015, 13, 6247-6258.

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