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Mar. Drugs 2015, 13(1), 338-353; doi:10.3390/md13010338

Preparation of Photocrosslinked Fish Elastin Polypeptide/Microfibrillated Cellulose Composite Gels with Elastic Properties for Biomaterial Applications

1
Department of Life and Environmental Sciences, Faculty of Engineering, Chiba Institute of Technology, 2-17-1 Tsudanuma, Narashino, Chiba 275-0016, Japan
2
Research & Development Division, Hayashikane Sangyo Co., Ltd., 2-4-8 Yamato-machi, Shimonoseki, Yamaguchi 750-8608, Japan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Hermann Ehrlich
Received: 14 November 2014 / Accepted: 26 December 2014 / Published: 9 January 2015
(This article belongs to the Special Issue Marine Biomaterials)
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Abstract

Photocrosslinked hydrogels reinforced by microfibrillated cellulose (MFC) were prepared from a methacrylate-functionalized fish elastin polypeptide and MFC dispersed in dimethylsulfoxide (DMSO). First, a water-soluble elastin peptide with a molecular weight of ca. 500 g/mol from the fish bulbus arteriosus was polymerized by N,N′-dicyclohexylcarbodiimide (DCC), a condensation reagent, and then modified with 2-isocyanatoethyl methacrylate (MOI) to yield a photocrosslinkable fish elastin polypeptide. The product was dissolved in DMSO and irradiated with UV light in the presence of a radical photoinitiator. We obtained hydrogels successfully by substitution of DMSO with water. The composite gel with MFC was prepared by UV irradiation of the photocrosslinkable elastin polypeptide mixed with dispersed MFC in DMSO, followed by substitution of DMSO with water. The tensile test of the composite gels revealed that the addition of MFC improved the tensile properties, and the shape of the stress–strain curve of the composite gel became more similar to the typical shape of an elastic material with an increase of MFC content. The rheology measurement showed that the elastic modulus of the composite gel increased with an increase of MFC content. The cell proliferation test on the composite gel showed no toxicity. View Full-Text
Keywords: elastin; fish peptide; microfibrillated cellulose; hydrogel; photocrosslinking; composite gel elastin; fish peptide; microfibrillated cellulose; hydrogel; photocrosslinking; composite gel
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yano, S.; Mori, M.; Teramoto, N.; Iisaka, M.; Suzuki, N.; Noto, M.; Kaimoto, Y.; Kakimoto, M.; Yamada, M.; Shiratsuchi, E.; Shimasaki, T.; Shibata, M. Preparation of Photocrosslinked Fish Elastin Polypeptide/Microfibrillated Cellulose Composite Gels with Elastic Properties for Biomaterial Applications. Mar. Drugs 2015, 13, 338-353.

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