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Mar. Drugs 2014, 12(8), 4399-4416; doi:10.3390/md12084399

Relative and Absolute Stereochemistry of Diacarperoxides: Antimalarial Norditerpene Endoperoxides from Marine Sponge Diacarnus megaspinorhabdosa

1
Key Laboratory for Marine Drugs, Department of Pharmacy, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
2
Department of Pharmacognosy and National Center for Natural Products Research (NCNPR), School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USA
3
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
4
Dujiangyan Center of Aeromedical Assessment and Training of Air Force, Dujiangyan 611830, China
5
Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 16 June 2014 / Revised: 24 July 2014 / Accepted: 25 July 2014 / Published: 8 August 2014
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Abstract

Five new norditerpene endoperoxides, named diacarperoxides H–L (15), and a new norditerpene diol, called diacardiol B (6), were isolated from the South China Sea sponge, Diacarnus megaspinorhabdosa. Their structures, including conformations and absolute configurations, were determined by using spectroscopic analyses, computational approaches and chemical degradation. Diacarperoxides H–J (13) showed some interesting stereochemical issues, as well as antimalarial activity. View Full-Text
Keywords: antimalarial; marine sponge; endoperoxide antimalarial; marine sponge; endoperoxide
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Yang, F.; Zou, Y.; Wang, R.-P.; Hamann, M.T.; Zhang, H.-J.; Jiao, W.-H.; Han, B.-N.; Song, S.-J.; Lin, H.-W. Relative and Absolute Stereochemistry of Diacarperoxides: Antimalarial Norditerpene Endoperoxides from Marine Sponge Diacarnus megaspinorhabdosa. Mar. Drugs 2014, 12, 4399-4416.

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