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Mar. Drugs 2014, 12(6), 3371-3380; doi:10.3390/md12063371

Numerosol A–D, New Cembranoid Diterpenes from the Soft Coral Sinularia numerosa

1
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
2
Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan
3
Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
4
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 4 March 2014 / Revised: 14 April 2014 / Accepted: 15 April 2014 / Published: 3 June 2014
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Abstract

Four new cembrane-type diterpenes; numerosol A–D (14); along with a known steroid; gibberoketosterol (5); were isolated from the Taiwanese soft coral Sinularia numerosa. The structures of these metabolites were determined by extensive analysis of spectroscopic data. Gibberoketosterol (5) exhibited cytotoxicity against P-388 (mouse lymphocytic leukemia) cell line with an ED50 of 6.9 μM. View Full-Text
Keywords: soft coral; Sinularia numerosa; numerosol A–D; gibberoketosterol; cytotoxicity soft coral; Sinularia numerosa; numerosol A–D; gibberoketosterol; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Tseng, Y.-J.; Yang, Y.-C.; Wang, S.-K.; Duh, C.-Y. Numerosol A–D, New Cembranoid Diterpenes from the Soft Coral Sinularia numerosa. Mar. Drugs 2014, 12, 3371-3380.

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