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Mar. Drugs 2014, 12(5), 3060-3071; doi:10.3390/md12053060

Klymollins T–X, Bioactive Eunicellin-Based Diterpenoids from the Soft Coral Klyxum molle

1
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
2
Agricultural Biotechnology Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan
3
Institute of Biotechnology, National Taiwan University, Taipei 106, Taiwan
4
Department of Life Science, National Central University, Taoyuan 320, Taiwan
5
Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
6
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan
7
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
8
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 4 January 2014 / Revised: 18 April 2014 / Accepted: 29 April 2014 / Published: 22 May 2014
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Abstract

Five new eunicellin-based diterpenoids, klymollins T–X (15), along with two known compounds (6 and 7) have been isolated from the soft coral Klyxum molle. The structures of these new metabolites were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. Compound 5 was found to exert significant in vitro anti-inflammatory activity against LPS-stimulated RAW264.7 macrophage cells. Furthermore, compounds 4 and 7 were shown to exhibit cytotoxicity against a limited panel of human cancer cell lines.
Keywords: soft coral; Klyxum molle; eunicellin-based diterpenoids; klymollins; cytotoxic activity; anti-inflammatory activity soft coral; Klyxum molle; eunicellin-based diterpenoids; klymollins; cytotoxic activity; anti-inflammatory activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Chang, F.-Y.; Hsu, F.-J.; Tai, C.-J.; Wei, W.-C.; Yang, N.-S.; Sheu, J.-H. Klymollins T–X, Bioactive Eunicellin-Based Diterpenoids from the Soft Coral Klyxum molle. Mar. Drugs 2014, 12, 3060-3071.

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