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Mar. Drugs 2014, 12(5), 3060-3071; doi:10.3390/md12053060
Article

Klymollins T–X, Bioactive Eunicellin-Based Diterpenoids from the Soft Coral Klyxum molle

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Received: 4 January 2014 / Revised: 18 April 2014 / Accepted: 29 April 2014 / Published: 22 May 2014
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Abstract

Five new eunicellin-based diterpenoids, klymollins T–X (15), along with two known compounds (6 and 7) have been isolated from the soft coral Klyxum molle. The structures of these new metabolites were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. Compound 5 was found to exert significant in vitro anti-inflammatory activity against LPS-stimulated RAW264.7 macrophage cells. Furthermore, compounds 4 and 7 were shown to exhibit cytotoxicity against a limited panel of human cancer cell lines.
Keywords: soft coral; Klyxum molle; eunicellin-based diterpenoids; klymollins; cytotoxic activity; anti-inflammatory activity soft coral; Klyxum molle; eunicellin-based diterpenoids; klymollins; cytotoxic activity; anti-inflammatory activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chang, F.-Y.; Hsu, F.-J.; Tai, C.-J.; Wei, W.-C.; Yang, N.-S.; Sheu, J.-H. Klymollins T–X, Bioactive Eunicellin-Based Diterpenoids from the Soft Coral Klyxum molle. Mar. Drugs 2014, 12, 3060-3071.

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